Neurokinin Receptors

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Catalog No.
Product Name
Application
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Product Citation
  1. neurokinin-1 receptor antagonist

    Aprepitant is classified as an NK1 antagonist. Aprepitant has been shown to inhibit both the acute and delayed emesis induced by cytotoxic chemotherapeutic drugs by blocking substance P landing on receptors in the brains neurons. It has also been shown to increase the activity of the 5-HT3 receptor antagonists ondansetron and the corticosteroid dexamethasone, which are also used to prevent nausea and vomiting caused by chemotherapy.

  2. neurokinin-1 receptor antagonist

    Fosaprepitant is a selective neurokinin-1 (NK-1) receptor antagonist.
  3. neurokinin-1 receptor antagonist

    Fosaprepitant (MK-0517, L-758,298) is a water-soluble phosphoryl prodrug for Aprepitant which is a NK1 antagonist.
  4. NK1 receptor antagonist

    GR 205171 is a selective neurokinin-1 receptor antagonist
  5. NK1 receptor antagonist

    Casopitant mesylate is the mesylate salt of a centrally-acting neurokinin 1 (NK1) receptor antagonist with antidepressant and antiemetic activities.
  6. tachykinin NK2 receptor antagonist

    Ibodutant is a tachykinin NK2 receptor antagonist for the treatment of Irritable Bowel Syndrome with diarrhoea (IBS-D)
  7. NK1R antagonist

    Befetupitant is a high-affinity, nonpeptide, competitive tachykinin 1 receptor (NK1R) antagonist.
  8. NK1 receptor antagonist

    Rolapitant, also known as SCH-619734, is a selective, bioavailable, CNS penetrant neurokinin NK1 receptor antagonist that shows behavioral effects in animals models of emesis.
  9. NK1 receptor antagonist

    GR203040 is a novel, potent and selective non-peptide tachykinin NK1 receptor antagonist.
  10. NK1 receptor antagonist

    Netupitant is a selective neurokinin 1 (NK1) receptor antagonist. It competitively binds to and blocks the activity of the human substance P/NK1 receptors in the central nervous system (CNS), thereby inhibiting NK1-receptor binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in the prevention of chemotherapy-induced nausea and vomiting (CINV).
  11. NK1 receptor antagonist

    NKP608 is a non-peptidic derivative of 4-aminopiperidine which acts as a selective, specific and potent antagonist at the neurokinin-1 (NK-1) receptor both in vitro(IC50=2.6 nM) and in vivo.
  12. NK3 receptor antagonist

    SB 222200 is a selective, reversible and competitive antagonist of human NK-3 receptor(Ki=4.4 nM) that effectively crosses the blood-brain barrier.
  13. NK3 receptor antagonist

    Talnetant is a potent and selective NK3 receptor antagonist(ki=1.4 nM, hNK-3-CHO); 100-fold selective for the hNK-3 versus hNK-2 receptor, with no affinity for the hNK-1 at concentrations up to 100 uM.
  14. NK3 receptor antagonist

    Talnetant Hcl is a potent and selective NK3 receptor antagonist(ki=1.4 nM, hNK-3-CHO); 100-fold selective for the hNK-3 versus hNK-2 receptor, with no affinity for the hNK-1 at concentrations up to 100 uM.
  15. NK1 receptor antagonist

    Tradipitant, also known as VLY-686 and LY686017, is the 2nd generation neurokinin-1 receptor antagonist, which showed activity in preclinical anxiety models.
  16. NK3 receptor agonist

    Senktide is a potent, selective agonist of the neuromedin K3 (NK3) receptor (EC50 = 0.5-3 nM).
  17. NK2 antagonist

    GR 159897 is a highly potent, selective, competitive, brain-penetrated non-peptide antagonist at tachykinin NK2 receptors, inhibits binding of [3H]GR100679 to hNK2-CHO cells and rat colon membranes with pKis of 9.51 and 10, respectively. Antagonizes bronchoconstriction, with anxiolytic-like activity.
  18. NK3R antagonist

    Pavinetant (MLE-4901) is a neurokinin-3 receptor (NK3R) antagonist.
  19. NK1 receptor antagonist

    Maropitant is a neurokinin (NK1) receptor antagonist.
  20. NK1 receptor antagonist

    Vofopitant dihydrochloride (GR 205171A) is a potent, selective and orally available tachykinin neurokinin 1(NK1) receptor antagonist.
  21. Neurokinin-1 (NK-1) receptor antagonist

    Serlopitant is a selective Neurokinin-1 (NK-1) receptor antagonist.

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