Target & Activity
| Target | Activity | Value |
|---|---|---|
| mTOR | N/A | |
| PI3Kα | 4 nM | |
| PI3Kγ | 38 nM | |
| PI3Kβ | 63 nM |
Fig. 1 · Structure
Documents & Downloads
NVP-BGT226
Cat. No.
A11162
CAS
1245537-68-1
PI3K inhibitor
NVP-BGT226, novel phosphoinositide 3-kinase/mTOR dual inhibitor, displays potent growth-inhibitory activity against human head and neck cancer cells in vitro and in vivo.
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Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1245537-68-1 |
| Applications | PI3K inhibitor |
| Formula | C28H25F3N6O2.C4H4O4 |
| Molecular Weight | 650.6 |
| Synonyms | BGT226 |
| SMILES | CN1C2=CN=C3C=CC(=CC3=C2N(C1=O)C4=CC(=C(C=C4)N5CCNCC5)C(F)(F)F)C6=CN=C(C=C6)OC.C(=C\C(=O)O)\C(=O)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
| Solvent | Reported Solubility |
|---|---|
| DMSO | 27 mg/mL (41.5 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
In Vivo Preparation
- Concentration
- 28 mg/mL
- Vehicle
- 30% PEG400+0.5% Tween80+5% propylene glycol
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.