PF-5274857

Smoothened Inhibitor

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Catalog No. A12775

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
PF-5274857 5mg A12775-5

Regular Price: $160.00

Special Price: $128.00

PF-5274857 10mg A12775-10

Regular Price: $225.00

Special Price: $180.00

PF-5274857 25mg A12775-25

Regular Price: $460.00

Special Price: $368.00

PF-5274857 50mg A12775-50

Regular Price: $930.00

Special Price: $744.00

PF-5274857 10mM * 1mL in DMSO A12775-10mM-D

Regular Price: $251.00

Special Price: $200.80

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

PF-5274857 is a novel Smo antagonist that specifically binds to Smo with a K(i) of 4.6 ± 1.1 nmol/L and completely blocks the transcriptional activity of the downstream gene Gli1 with an IC(50) of 2.7 ± 1.4 nmol/L in cells.

PF-5274857

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Chemical Information

Catalog Num A12775
Actions Inhibitor
M. Wt 436.96
Formula C20H25ClN4O3S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1373615-35-0
Synonyms PF5274857, PF 5274857
SMILES code CC1=CC(=C(N=C1)C2=CC(=NC=C2Cl)N3CCN(CC3)C(=O)CCS(=O)(=O)C)C
Chemical Name 1-(4-(5-chloro-4-(3,5-diMethylpyridin-2-yl)pyridin-2-yl)piperazin-1-yl)-3-(Methylsulfonyl)propan-1-one

Biological Activity

Description
PF-5274857 is a novel Smo antagonist that specifically binds to Smo with a K(i) of 4.6 ± 1.1 nmol/L and completely blocks the transcriptional activity of the downstream gene Gli1 with an IC(50) of 2.7 ± 1.4 nmol/L in cells.
Targets
Smoothened Smoothened
4.6 nM(Ki)5.8 nM

Solubility

Solubility (25°C) * In vitro DMSO 93 mg/mL (212.83 mM)
Water 93 mg/mL (212.83 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo Saline 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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