PHA 408

IKK-2 inhibitor

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Catalog No. A13108

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
PHA 408 5mg A13108-5

Regular Price: $120.00

Special Price: $102.00

PHA 408 10mg A13108-10

Regular Price: $220.00

Special Price: $187.00

PHA 408 25mg A13108-25

Regular Price: $450.00

Special Price: $382.50

PHA 408 50mg A13108-50

Regular Price: $750.00

Special Price: $637.50

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

PHA 408 is a potent, highly selective and ATP-competitive IKB kinase-2 (IKK-2) inhibitor (IC50: 40 nM), which binds IKK-2 tightly with a relatively slow off rate; highly recommended tool to investigate the mechanisms by which IKK-2 regulates NF-KB signaling.

PHA 408

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Chemical Information

Catalog Num A13108
Actions Inhibitor
M. Wt 560.02
Formula C29H27ClFN7O2
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 503555-55-3
Synonyms PHA-408, PHA408
SMILES code CN1CCN(CC1)C2=NC=C(C(=C2)C(=O)NC3=CC4=C(CCC5=C4N(N=C5C(=O)N)C6=CC=C(C=C6)F)C=C3)Cl
Chemical Name 8-(5-chloro-2-(4-methylpiperazin-1-yl)isonicotinamido)-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide

Biological Activity

Description
PHA 408 is a potent, highly selective and ATP-competitive IKB kinase-2 (IKK-2) inhibitor (IC50: 40 nM), which binds IKK-2 tightly with a relatively slow off rate; highly recommended tool to investigate the mechanisms by which IKK-2 regulates NF-KB signaling.

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