IκK/IκB

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Catalog No.
Product Name
Application
Product Information
Product Citation
  1. PDK-1 inhibitor

    BX-795 is a potent PDK1 inhibitor that blocks PDK1/Akt signaling in tumor cells and inhibits the anchorage-dependent growth of a variety of tumor cell lines in culture or induced apoptosis.
  2. IKK inhibitor

    BMS 345541 is a cell-permeable and highly selective IKB kinase (IKK) inhibitor that binds at allosteric site of the enzyme and blocks NF-kB-dependent transcription in mice.
  3. IκB/IKK inhibitor

    Bardoxolone methyl is an orally-available first-in-class synthetic triterpenoid. It is an inducer of the Nrf2 pathway, which can suppress oxidative stress and inflammation.
  4. IκB/IKK inhibitor

    Bardoxolone methyl, previously known as RTA 402, is the lead molecule in Reata's portfolio of Antioxidant Inflammation Modulators (AIMs).
  5. IKKβ kinase inhibitor

    Bay 65-1942 is an ATP-competitive inhibitor that selectively targets IKKβ kinase activity.
  6. IKKβ inhibitor

    Bay 65-1942 is an ATP-competitive inhibitor that selectively targets IKKβ kinase activity.
  7. IKK Inhibitor

    IKK-2 inhibitor VIII is a potent and selective IKK-2 inhibitor with IC50 of 8.5 nM.
  8. IKK Inhibitor

    IKK-3 Inhibitor is a potent, selective, inhibitor of IKK-epsilon kinase with IC50 of 40 nM; inactive at IKK-alpha and IKK-beta.
  9. SIK/TBK-1/IKKe inhibitor

    MRT67307 is a potent and dual IKKε and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively.
  10. IKK-2 inhibitor

    TPCA-1 is a potent and selective inhibitor of human IκB kinase-2 (IKK-2) with IC50 = 17.9 nM for IKK-2 compared to 400nm for IKK-1.
  11. E2 ubiquitin conjugating enzyme inhibitor

    Bay 11-7821 is an irreversible inhibitor of TNF-α-stimulated IκBα phosphorylation.
  12. IκB/IKK inhibitor

    BAY 11-7085 is an irreversible inhibitor of TNFα-induced IκBα phosphorylation with IC50 of 10 μM
  13. IKK2/IKK1 inhibitor

    BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM
  14. IκB/IKK Inhibitor

    SC-514 is an orally active, ATP-competitive IKKβ inhibitor (IC50 = 3 - 12 μM) that displays > 10-fold selectivity over 28 other kinases including JNK, p38, MK2 and ERK.
  15. IKK inhibitor

    PS-1145 is a highly specific IKB kinase (IKK) inhibitor that efficiently inhibits both basal and induced NF-kB activity in PC cells.
  16. IKK Inhibitor

    IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.
  17. IKK Inhibitor

    IMD 0354 is an inhibitor of IκB kinase-β (IKKβ) that blocks NF-κB nuclear translocation.
  18. EBP1 Inhibitor

    WS3 is a β cell proliferation inducer via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.
  19. EBP1 Inhibitor

    WS6 is a β cell proliferation inducer via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.
  20. IKK-2 inhibitor

    PHA 408 is a potent, highly selective and ATP-competitive IKB kinase-2 (IKK-2) inhibitor (IC50: 40 nM), which binds IKK-2 tightly with a relatively slow off rate; highly recommended tool to investigate the mechanisms by which IKK-2 regulates NF-KB signaling.
  21. IKKβ inhibitor

    BI605906 is a novel inhibitors of the IKK beta.
  22. IKK Inhibitor II

    Wedelolactone, a compound originally extracted from Eclipta alba, has been shown to inhibit caspase-11, which is a key regulator of proinflammatory cytokine IL-1β maturation and pathological apoptosis.
  23. IKK Inhibitor?€?

    Bay 65-1942 (R form) is an ATP-competitive inhibitor that selectively targets IKKβ kinase.
  24. IκB Kinase β Inhibitor

    MLN120B is a potent and effective IKKbeta inhibitor.
  25. IKK2 inhibitor

    LY2409881 is a potent and selective IKK2 inhibitor with IC50 of 30 nM, >10-fold selectivity over IKK1 and other common kinases.
  26. IKK2 inhibitor?€?

    AZD3264 is a novel IKK2 inhibitor.
  27. IKKε /TBK1 inhibitor

    Amlexanox is an anti-inflammatory antiallergic immunomodulator used to treat recurrent aphthous ulcers (canker sores), and (in Japan) several inflammatory conditions.
  28. IKK-ε inhibitor

    IKK epsilon-IN-1 is a potent IKKε inhibitor; inhibit the in-situ IKK ε-mediated phosphorylation of IRF3 with an IC50 value of less than about 100 nM.
  29. Nrf2 activator

    CDDO-EA is an activator of Nrf2/ARE; Neuroprotective effect.
  30. dual TBK1 and IKKε inhibitor

    TBK1/IKKε-IN-5 is a dual TBK1 and IKKε inhibitor, with IC50 values of 1 nM and 5.6 nM for TBK1 and IKKε, respectively.
  31. IKKα/IKKβ inhibitor

    INH14 is a cell permeable inhibitor of IKKα/IKKβ, with IC50s of 8.97 and 3.59 μM, respectively.
  32. IκB kinase β inhibitor

    IMD-0560 is a novel IκB kinase β inhibitor.
  33. TBK1 inhibitor

    GSK8612 is a highly selective and potent Tank-binding Kinase-1 (TBK1) inhibitor, with a pIC50 of 6.8 for recombinant TBK1.
  34. IKK inhibitor

    IKK-IN-1 is an inhibitor of IKK extracted from patent WO2002024679A1, compound example 18-13.
  35. IKK2/IKK complex/IKK1 inhibitor

    IKK 16 hydrochloride is a selective IκB kinase (IKK) inhibitor for IKK2, IKK complex and IKK1 with IC50s of 40 nM, 70 nM and 200 nM, respectively.
  36. IKKβ/Tyk2 pseudokinase inhibitor

    BMS-066 is an IKKβ/Tyk2 pseudokinase inhibitor, with IC50s of 9 nM and 72 nM, respectively.
  37. IκBα ubiquitination inhibitor

    GS143 is a selec?tive IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation.

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