IκK/IκB

Cat. No.

A11323

CAS No.

218600-53-4

Bardoxolone methyl (RTA 402)

Synonyms: NSC 713200; CDDO-methyl ester; RTA 402

Bardoxolone methyl is an orally-available first-in-class synthetic triterpenoid. It is an inducer of the Nrf2 pathway, which can suppress oxidative stress and inflammation.

Cat. No.

A11957

CAS No.

19542-67-7

Bay 11-7821

Synonyms: Bay 11-7082

Bay 11-7821 is an irreversible inhibitor of TNF-α-stimulated IκBα phosphorylation.

Cat. No.

A11324

CAS No.

218600-44-3

Bardoxolone (CDDO)

Synonyms: RTA 401; CDDO

Bardoxolone methyl, previously known as RTA 402, is the lead molecule in Reata's portfolio of Antioxidant Inflammation Modulators (AIMs).

Cat. No.

A11148

CAS No.

702675-74-9

BX-795

BX-795 is a potent PDK1 inhibitor that blocks PDK1/Akt signaling in tumor cells and inhibits the anchorage-dependent growth of a variety of tumor cell lines in culture or induced apoptosis.

Cat. No.

A11318

CAS No.

547757-23-3

BMS-345541 HCl

Synonyms: BMS345541

BMS 345541 is a cell-permeable and highly selective IKB kinase (IKK) inhibitor that binds at allosteric site of the enzyme and blocks NF-kB-dependent transcription in mice.

Cat. No.

A11579

CAS No.

507475-17-4

TPCA-1

TPCA-1 is a potent and selective inhibitor of human IκB kinase-2 (IKK-2) with IC50 = 17.9 nM for IKK-2 compared to 400nm for IKK-1.

Cat. No.

A12470

CAS No.

196309-76-9

BAY 11-7085

Synonyms: Bay 11-7083

BAY 11-7085 is an irreversible inhibitor of TNFα-induced IκBα phosphorylation with IC50 of 10 μM

Cat. No.

A12836

CAS No.

873225-46-8

IKK-16

IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.

Cat. No.

A12837

CAS No.

978-62-1

IMD 0354

IMD 0354 is an inhibitor of IκB kinase-β (IKKβ) that blocks NF-κB nuclear translocation.

Cat. No.

A14804

CAS No.

524-12-9

Wedelolactone

Synonyms: IKK Inhibitor II; Eclipta alba

Wedelolactone, a compound originally extracted from Eclipta alba, has been shown to inhibit caspase-11, which is a key regulator of proinflammatory cytokine IL-1β maturation and pathological apoptosis.

Cat. No.

A11338

CAS No.

600734-06-3

Bay 65-1942 HCl

Bay 65-1942 is an ATP-competitive inhibitor that selectively targets IKKβ kinase activity.

Cat. No.

A11339

CAS No.

600734-02-9

Bay 65-1942

Bay 65-1942 is an ATP-competitive inhibitor that selectively targets IKKβ kinase activity.

Cat. No.

A11452

CAS No.

406209-26-5

ACHP Hydrochloride (IKK-2 inhibitor VIII)

Synonyms: IKK-beta inhibitor; IKK-2 inhibitor VIII

IKK-2 inhibitor VIII is a potent and selective IKK-2 inhibitor with IC50 of 8.5 nM.

Cat. No.

A11463

CAS No.

862812-98-4

GSK319347A (CAY10576)

Synonyms: CAY10576

GSK319347A (CAY10576) is a potent, selective, inhibitor of IKK-epsilon kinase with IC50 of 40 nM; inactive at IKK-alpha and IKK-beta.  

Cat. No.

A11485

CAS No.

1190378-57-4

MRT67307

MRT67307 is a potent and dual IKKε and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively.

Cat. No.

A12559

CAS No.

445430-58-0

BMS-345541

BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM

Cat. No.

A12746

CAS No.

354812-17-2

SC-514

SC-514 is an orally active, ATP-competitive IKKβ inhibitor (IC50 = 3 - 12 μM) that displays > 10-fold selectivity over 28 other kinases including JNK, p38, MK2 and ERK.

Cat. No.

A12789

CAS No.

431898-65-6

PS-1145

PS-1145 is a highly specific IKB kinase (IKK) inhibitor that efficiently inhibits both basal and induced NF-kB activity in PC cells.

Cat. No.

A12952

CAS No.

1421227-52-2

WS3

WS3 is a β cell proliferation inducer via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.

Cat. No.

A12953

CAS No.

1421227-53-3

WS6

WS6 is a β cell proliferation inducer via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.

Cat. No.

A13108

CAS No.

503555-55-3

PHA 408

PHA 408 is a potent, highly selective and ATP-competitive IKB kinase-2 (IKK-2) inhibitor (IC50: 40 nM), which binds IKK-2 tightly with a relatively slow off rate; highly recommended tool to investigate the mechanisms by which IKK-2 regulates NF-KB signaling.

Cat. No.

A13537

CAS No.

960293-88-3

BI605906

BI605906 is a novel inhibitors of the IKK beta.

Cat. No.

A15018

CAS No.

758683-21-5

Bay 65-1942 R form

Synonyms: Bay 65-1942

Bay 65-1942 (R form) is an ATP-competitive inhibitor that selectively targets IKKβ kinase.

Cat. No.

A15171

CAS No.

783348-36-7

MLN120B

Synonyms: ML120B

MLN120B is a potent and effective IKKbeta inhibitor.

Cat. No.

A15488

CAS No.

946518-60-1

LY2409881 trihydrochloride

Synonyms: LY-2409881

LY2409881 is a potent and selective IKK2 inhibitor with IC50 of 30 nM, >10-fold selectivity over IKK1 and other common kinases.