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$0.00 NF-kB/IkB
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JSH 23
Catalog No. A14142 NF-κB inhibitorJSH 23 is an inhibitor of NF-kB, blocking its translocation into the nucleus (IC50 = 7.1 uM) Learn More -
SC75741
Catalog No. A14278 NF-κB inhibitorSC75741 is a potent NF-kB inhibitor with EC50 of 200 nM. Learn More -
CID-2858522
Catalog No. A15046 NF-κB inhibitorCID-2858522 selectively inhibits the NF-κB pathway (IC50 < 0.1 uM for PMA-stimulated IL-8 production) induced by PKC, operating downstream of PKC but upstream of IKKbeta, without inhibiting other NF-kappaB activation pathways. Learn More -
(+)-DHMEQ
Catalog No. A16301 NF-kB inhibitorThe (+)-DHMEQ, the distomer of DHMEQ, is a inhibitor of NF-kB. Learn More -
(-)-DHMEQ
Catalog No. A16302 NF-kB inhibitor(-)-DHMEQ, the eutomer of DHMEQ , is a newly developed NF-kB inhibitor, inhibits nuclear factor kB activation with IC50 value of 20 ug/mL, the activity is stronger than (+)-DHMEQ (HY-14645A). Learn More -
Pyrrolidinedithiocarbamate ammonium
Catalog No. A16306 NF-kB inhibitorPyrrolidinedithiocarbamate ammonium is a selective NF-kB inhibitor, inhibits translation of nitric oxide synthase mRNA to prevent induction. Learn More -
Andrographolide
Catalog No. A10077 Apoptosis InducerAndrographolide is an interesting pharmacophore with anticancer and immunomodulatory activities and hence has the potential for being developed as a cancer therapeutic agent. Learn More -
Parthenolide ((-)-Parthenolide)
Catalog No. A10698 Parthenolide ((-)-Parthenolide) is a sesquiterpene lactone which occurs naturally in the plant feverfew (Tanacetum parthenium). Learn More -
QNZ (EVP4593)
Catalog No. A12748 NF-κB inhibitorQNZ inhibits the activation of the transcription factor NF-κB and has been used to investigate NF-κB signaling. Learn More -
Caffeic Acid Phenethyl Ester
Catalog No. A13698 NF-κB activation inhibitorCaffeic acid phenethyl ester is a potent and specific inhibitor of NF-κB activation Learn More -
Dehydrocostus Lactone
Catalog No. A14809 Dehydrocostus Lactone inhibits NF kappa B activation by preventing TNF-α induced degradation and phosphorylation. Learn More -
Tomatidine
Catalog No. A16233 ERK/Akt/NF-kB inhibitorTomatidine inhibits the phosphorylation of ERK, Akt, and the nuclear content of NF-kB. possess anti-inflammatory properties. Learn More -
Adjudin
Catalog No. A16303 Adjudin is a drug which is under development as a potential non-hormonal male contraceptive drug, which acts by blocking the production of sperm in the testes, but without affecting testosterone production. Learn More -
CBL-0137
Catalog No. A16836 p53 activator / NF-κB inhibitorCBL0137(CBL-0137) activates p53 and inhibits NF-kB with EC50s of 0.37 μM and 0.47 μM in the cell-based p53 and NF-kB reporter assays, respectively. It also inhibits histone chaperone FACT (facilitates chromatin transcription complex). Learn More -
Ac2-26
Catalog No. A17205 NF-κB InhibitorAc2-26 is an active N-terminal peptide of annexin A1 (AnxA1). Learn More -
Bardoxolone methyl (RTA 402)
Catalog No. A11323 IκB/IKK inhibitorBardoxolone methyl is an orally-available first-in-class synthetic triterpenoid. It is an inducer of the Nrf2 pathway, which can suppress oxidative stress and inflammation. Learn More -
Bay 65-1942
Catalog No. A11339 IKKβ inhibitorBay 65-1942 is an ATP-competitive inhibitor that selectively targets IKKβ kinase activity. Learn More -
BMS-345541 HCl
Catalog No. A11318 IKK inhibitorBMS 345541 is a cell-permeable and highly selective IKB kinase (IKK) inhibitor that binds at allosteric site of the enzyme and blocks NF-kB-dependent transcription in mice. Learn More -
Bay 65-1942 HCl
Catalog No. A11338 IKKβ kinase inhibitorBay 65-1942 is an ATP-competitive inhibitor that selectively targets IKKβ kinase activity. Learn More -
Bardoxolone (CDDO)
Catalog No. A11324 IκB/IKK inhibitorBardoxolone methyl, previously known as RTA 402, is the lead molecule in Reata's portfolio of Antioxidant Inflammation Modulators (AIMs). Learn More -
Wedelolactone
Catalog No. A14804 IKK Inhibitor IIWedelolactone, a compound originally extracted from Eclipta alba, has been shown to inhibit caspase-11, which is a key regulator of proinflammatory cytokine IL-1β maturation and pathological apoptosis. Learn More -
Bay 65-1942 R form
Catalog No. A15018 IKK InhibitorBay 65-1942 (R form) is an ATP-competitive inhibitor that selectively targets IKKβ kinase. Learn More -
MLN120B
Catalog No. A15171 -
LY2409881
Catalog No. A15488 IKK2 inhibitorLY2409881 is a potent and selective IKK2 inhibitor with IC50 of 30 nM, >10-fold selectivity over IKK1 and other common kinases. Learn More -
AZD3264
Catalog No. A15900 -
MRT67307
Catalog No. A11485 SIK/TBK-1/IKKe inhibitorMRT67307 is a potent and dual IKKϵ and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively. Learn More -
IKK-2 inhibitor VIII
Catalog No. A11452 IKK InhibitorIKK-2 inhibitor VIII is a potent and selective IKK-2 inhibitor with IC50 of 8.5 nM. Learn More -
IKK-3 Inhibitor
Catalog No. A11463 IKK InhibitorIKK-3 Inhibitor is a potent, selective, inhibitor of IKK-epsilon kinase with IC50 of 40 nM; inactive at IKK-alpha and IKK-beta. Learn More -
IKK epsilon-IN-1
Catalog No. A16298 IKK-ε inhibitorIKK epsilon-IN-1 is a potent IKKε inhibitor; inhibit the in-situ IKK ε-mediated phosphorylation of IRF3 with an IC50 value of less than about 100 nM. Learn More -
BMS-066
Catalog No. A21972 IKKβ/Tyk2 pseudokinase inhibitorBMS-066 is an IKKβ/Tyk2 pseudokinase inhibitor, with IC50s of 9 nM and 72 nM, respectively. Learn More -
BX-795
Catalog No. A11148 PDK-1 inhibitorBX-795 is a potent PDK1 inhibitor that blocks PDK1/Akt signaling in tumor cells and inhibits the anchorage-dependent growth of a variety of tumor cell lines in culture or induced apoptosis. Learn More -
Bay 11-7821
Catalog No. A11957 E2 ubiquitin conjugating enzyme inhibitorBay 11-7821 is an irreversible inhibitor of TNF-α-stimulated IκBα phosphorylation. Learn More -
SC-514
Catalog No. A12746 IκB/IKK InhibitorSC-514 is an orally active, ATP-competitive IKKβ inhibitor (IC50 = 3 - 12 μM) that displays > 10-fold selectivity over 28 other kinases including JNK, p38, MK2 and ERK. Learn More -
IKK-16
Catalog No. A12836 IKK InhibitorIKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively. Learn More -
IMD 0354
Catalog No. A12837 IKK InhibitorIMD 0354 is an inhibitor of IκB kinase-β (IKKβ) that blocks NF-κB nuclear translocation. Learn More -
PHA 408
Catalog No. A13108 IKK-2 inhibitorPHA 408 is a potent, highly selective and ATP-competitive IKB kinase-2 (IKK-2) inhibitor (IC50: 40 nM), which binds IKK-2 tightly with a relatively slow off rate; highly recommended tool to investigate the mechanisms by which IKK-2 regulates NF-KB signaling. Learn More -
TPCA-1
Catalog No. A11579 IKK-2 inhibitorTPCA-1 is a potent and selective inhibitor of human IκB kinase-2 (IKK-2) with IC50 = 17.9 nM for IKK-2 compared to 400nm for IKK-1. Learn More -
WS3
Catalog No. A12952 EBP1 InhibitorWS3 is a β cell proliferation inducer via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway. Learn More -
WS6
Catalog No. A12953 EBP1 InhibitorWS6 is a β cell proliferation inducer via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway. Learn More -
BAY 11-7085
Catalog No. A12470 IκB/IKK inhibitorBAY 11-7085 is an irreversible inhibitor of TNFα-induced IκBα phosphorylation with IC50 of 10 μM Learn More -
BMS-345541
Catalog No. A12559 IKK2/IKK1 inhibitorBMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM Learn More -
BI605906
Catalog No. A13537 -
PS-1145
Catalog No. A12789 IKK inhibitorPS-1145 is a highly specific IKB kinase (IKK) inhibitor that efficiently inhibits both basal and induced NF-kB activity in PC cells. Learn More -
Amlexanox
Catalog No. A16297 IKKε /TBK1 inhibitorAmlexanox is an anti-inflammatory antiallergic immunomodulator used to treat recurrent aphthous ulcers (canker sores), and (in Japan) several inflammatory conditions. Learn More -
CDDO-EA
Catalog No. A16299 -
TBK1/IKKε-IN-5
Catalog No. A18400 dual TBK1 and IKKε inhibitorTBK1/IKKε-IN-5 is a dual TBK1 and IKKε inhibitor, with IC50 values of 1 nM and 5.6 nM for TBK1 and IKKε, respectively. Learn More -
INH14
Catalog No. A19119 IKKα/IKKβ inhibitorINH14 is a cell permeable inhibitor of IKKα/IKKβ, with IC50s of 8.97 and 3.59 μM, respectively. Learn More -
IKK-IN-1
Catalog No. A21221 IKK inhibitorIKK-IN-1 is an inhibitor of IKK extracted from patent WO2002024679A1, compound example 18-13. Learn More -
IKK 16 hydrochloride
Catalog No. A21588 IKK2/IKK complex/IKK1 inhibitorIKK 16 hydrochloride is a selective IκB kinase (IKK) inhibitor for IKK2, IKK complex and IKK1 with IC50s of 40 nM, 70 nM and 200 nM, respectively. Learn More -
MS-275 (Entinostat)
Catalog No. A10611 HDAC inhibitorMS-275 (Entinostat) is a potent HDAC inhibitor with IC50 of 0.3 and 8uM for HDAC1 and HDAC3, respectively. Learn More
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