Items 1 to 50 of 102 total

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  1. JSH 23

    Catalog No. A14142
    NF-κB inhibitor
    JSH 23 is an inhibitor of NF-kB, blocking its translocation into the nucleus (IC50 = 7.1 uM) Learn More
  2. SC75741

    Catalog No. A14278
    NF-κB inhibitor
    SC75741 is a potent NF-kB inhibitor with EC50 of 200 nM. Learn More
  3. CID-2858522

    Catalog No. A15046
    NF-κB inhibitor
    CID-2858522 selectively inhibits the NF-κB pathway (IC50 < 0.1 uM for PMA-stimulated IL-8 production) induced by PKC, operating downstream of PKC but upstream of IKKbeta, without inhibiting other NF-kappaB activation pathways. Learn More
  4. (+)-DHMEQ

    Catalog No. A16301
    NF-kB inhibitor
    The (+)-DHMEQ, the distomer of DHMEQ, is a inhibitor of NF-kB. Learn More
  5. (-)-DHMEQ

    Catalog No. A16302
    NF-kB inhibitor
    (-)-DHMEQ, the eutomer of DHMEQ , is a newly developed NF-kB inhibitor, inhibits nuclear factor kB activation with IC50 value of 20 ug/mL, the activity is stronger than (+)-DHMEQ (HY-14645A). Learn More
  6. NF-kB inhibitor
    Pyrrolidinedithiocarbamate ammonium is a selective NF-kB inhibitor, inhibits translation of nitric oxide synthase mRNA to prevent induction. Learn More
  7. Andrographolide

    Catalog No. A10077
    Apoptosis Inducer
    Andrographolide is an interesting pharmacophore with anticancer and immunomodulatory activities and hence has the potential for being developed as a cancer therapeutic agent. Learn More
  8. Parthenolide ((-)-Parthenolide) is a sesquiterpene lactone which occurs naturally in the plant feverfew (Tanacetum parthenium). Learn More
  9. QNZ (EVP4593)

    Catalog No. A12748
    NF-κB inhibitor
    QNZ inhibits the activation of the transcription factor NF-κB and has been used to investigate NF-κB signaling. Learn More
  10. NF-κB activation inhibitor
    Caffeic acid phenethyl ester is a potent and specific inhibitor of NF-κB activation Learn More
  11. Dehydrocostus Lactone

    Catalog No. A14809
    Dehydrocostus Lactone inhibits NF kappa B activation by preventing TNF-α induced degradation and phosphorylation. Learn More
  12. Tomatidine

    Catalog No. A16233
    ERK/Akt/NF-kB inhibitor
    Tomatidine inhibits the phosphorylation of ERK, Akt, and the nuclear content of NF-kB. possess anti-inflammatory properties. Learn More
  13. Adjudin

    Catalog No. A16303
    Adjudin is a drug which is under development as a potential non-hormonal male contraceptive drug, which acts by blocking the production of sperm in the testes, but without affecting testosterone production. Learn More
  14. CBL-0137

    Catalog No. A16836
    p53 activator / NF-κB inhibitor
    CBL0137(CBL-0137) activates p53 and inhibits NF-kB with EC50s of 0.37 μM and 0.47 μM in the cell-based p53 and NF-kB reporter assays, respectively. It also inhibits histone chaperone FACT (facilitates chromatin transcription complex). Learn More
  15. Ac2-26

    Catalog No. A17205
    NF-κB Inhibitor
    Ac2-26 is an active N-terminal peptide of annexin A1 (AnxA1). Learn More
  16. IκB/IKK inhibitor
    Bardoxolone methyl is an orally-available first-in-class synthetic triterpenoid. It is an inducer of the Nrf2 pathway, which can suppress oxidative stress and inflammation. Learn More
  17. Bay 65-1942

    Catalog No. A11339
    IKKβ inhibitor
    Bay 65-1942 is an ATP-competitive inhibitor that selectively targets IKKβ kinase activity. Learn More
  18. BMS-345541 HCl

    Catalog No. A11318
    IKK inhibitor
    BMS 345541 is a cell-permeable and highly selective IKB kinase (IKK) inhibitor that binds at allosteric site of the enzyme and blocks NF-kB-dependent transcription in mice. Learn More
  19. Bay 65-1942 HCl

    Catalog No. A11338
    IKKβ kinase inhibitor
    Bay 65-1942 is an ATP-competitive inhibitor that selectively targets IKKβ kinase activity. Learn More
  20. Bardoxolone (CDDO)

    Catalog No. A11324
    IκB/IKK inhibitor
    Bardoxolone methyl, previously known as RTA 402, is the lead molecule in Reata's portfolio of Antioxidant Inflammation Modulators (AIMs). Learn More
  21. Wedelolactone

    Catalog No. A14804
    IKK Inhibitor II
    Wedelolactone, a compound originally extracted from Eclipta alba, has been shown to inhibit caspase-11, which is a key regulator of proinflammatory cytokine IL-1?? maturation and pathological apoptosis. Learn More
  22. Bay 65-1942 R form

    Catalog No. A15018
    IKK Inhibitor‎
    Bay 65-1942 (R form) is an ATP-competitive inhibitor that selectively targets IKKβ kinase. Learn More
  23. MLN120B

    Catalog No. A15171
    IκB Kinase β Inhibitor
    MLN120B is a potent and effective IKKbeta inhibitor. Learn More
  24. LY2409881

    Catalog No. A15488
    IKK2 inhibitor
    LY2409881 is a potent and selective IKK2 inhibitor with IC50 of 30 nM, >10-fold selectivity over IKK1 and other common kinases. Learn More
  25. AZD3264

    Catalog No. A15900
    IKK2 inhibitor‎
    AZD3264 is a novel IKK2 inhibitor. Learn More
  26. MRT67307

    Catalog No. A11485
    SIK/TBK-1/IKKe inhibitor
    MRT67307 is a potent and dual IKKϵ and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively. Learn More
  27. IKK-2 inhibitor VIII

    Catalog No. A11452
    IKK Inhibitor
    IKK-2 inhibitor VIII is a potent and selective IKK-2 inhibitor with IC50 of 8.5 nM. Learn More
  28. IKK-3 Inhibitor

    Catalog No. A11463
    IKK Inhibitor
    IKK-3 Inhibitor is a potent, selective, inhibitor of IKK-epsilon kinase with IC50 of 40 nM; inactive at IKK-alpha and IKK-beta. Learn More
  29. IKK epsilon-IN-1

    Catalog No. A16298
    IKK-ε inhibitor
    IKK epsilon-IN-1 is a potent IKKε inhibitor; inhibit the in-situ IKK ε-mediated phosphorylation of IRF3 with an IC50 value of less than about 100 nM. Learn More
  30. BX-795

    Catalog No. A11148
    PDK-1 inhibitor
    BX-795 is a potent PDK1 inhibitor that blocks PDK1/Akt signaling in tumor cells and inhibits the anchorage-dependent growth of a variety of tumor cell lines in culture or induced apoptosis. Learn More
  31. Bay 11-7821

    Catalog No. A11957
    E2 ubiquitin conjugating enzyme inhibitor
    Bay 11-7821 is an irreversible inhibitor of TNF-α-stimulated IκBα phosphorylation. Learn More
  32. SC-514

    Catalog No. A12746
    IκB/IKK Inhibitor
    SC-514 is an orally active, ATP-competitive IKKβ inhibitor (IC50 = 3 - 12 μM) that displays > 10-fold selectivity over 28 other kinases including JNK, p38, MK2 and ERK. Learn More
  33. IKK-16

    Catalog No. A12836
    IKK Inhibitor
    IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively. Learn More
  34. IMD 0354

    Catalog No. A12837
    IKK Inhibitor
    IMD 0354 is an inhibitor of IκB kinase-β (IKKβ) that blocks NF-κB nuclear translocation. Learn More
  35. PHA 408

    Catalog No. A13108
    IKK-2 inhibitor
    PHA 408 is a potent, highly selective and ATP-competitive IKB kinase-2 (IKK-2) inhibitor (IC50: 40 nM), which binds IKK-2 tightly with a relatively slow off rate; highly recommended tool to investigate the mechanisms by which IKK-2 regulates NF-KB signaling. Learn More
  36. WS3

    Catalog No. A12952
    EBP1 Inhibitor
    WS3 is a β cell proliferation inducer via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway. Learn More
  37. WS6

    Catalog No. A12953
    EBP1 Inhibitor
    WS6 is a β cell proliferation inducer via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway. Learn More
  38. BAY 11-7085

    Catalog No. A12470
    κB/IKK inhibitor
    BAY 11-7085 is an irreversible inhibitor of TNFα-induced IκBα phosphorylation with IC50 of 10 μM Learn More
  39. BMS-345541

    Catalog No. A12559
    IKK2/IKK1 inhibitor
    BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM Learn More
  40. BI605906

    Catalog No. A13537
    IKKβ inhibitor
    BI605906 is a novel inhibitors of the IKK beta. Learn More
  41. PS-1145

    Catalog No. A12789
    IKK inhibitor
    PS-1145 is a highly specific IKB kinase (IKK) inhibitor that efficiently inhibits both basal and induced NF-kB activity in PC cells. Learn More
  42. Amlexanox

    Catalog No. A16297
    IKKε /TBK1 inhibitor
    Amlexanox is an anti-inflammatory antiallergic immunomodulator used to treat recurrent aphthous ulcers (canker sores), and (in Japan) several inflammatory conditions. Learn More
  43. CDDO-EA

    Catalog No. A16299
    Nrf2 activator
    CDDO-EA is an activator of Nrf2/ARE; Neuroprotective effect. Learn More
  44. MS-275 (Entinostat)

    Catalog No. A10611
    HDAC inhibitor
    MS-275 (Entinostat) is a potent HDAC inhibitor with IC50 of 0.3 and 8uM for HDAC1 and HDAC3, respectively. Learn More
  45. Trichostatin-A (TSA)

    Catalog No. A10947
    HDAC Inhibitor
    Trichostatin A (TSA) inhibits the HDACs 1, 3, 4, 6 and 10 with IC50 values around 20 nM. Learn More
  46. Belinostat (PXD101)

    Catalog No. A10122
    HDAC inhibitor
    Belinostat (PXD101) is a HDAC inhibitor that inhibits HDAC activity in HeLa cell extracts with an IC50 of 27 nM. Learn More
  47. LBH589 (Panobinostat)

    Catalog No. A10518
    HDAC Inhibitor
    LBH589 is a hydroxamic acid and acts as a non-selective HDAC inhibitor with IC5o of HDAC1 to be 0.23 nM. Learn More
  48. MC1568

    Catalog No. A10560
    HDAC Inhibitor
    MC1568 is a member of HDAC inhibitors that inhibits the histone deacetylase class II by modifying the genetic expression of various important genes of cell cycle mostly at G1 phase, resulting in the death of breast cancer cells by apoptosis. Learn More
  49. CUDC-101

    Catalog No. A10246
    HDAC inhibitor
    CUDC-101 is a novel compound which inhibits multiple targets, which is designed to inhibit HDAC, EGFR and Her2. Learn More

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