PKI-587 ( Gedatolisib ) ON SALE PI3K/mTOR inhibitor

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Catalog No. A11079

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
PKI-587 5mg A11079-5

Regular Price: $90.00

Special Price: $76.50

PKI-587 10mg A11079-10

Regular Price: $160.00

Special Price: $136.00

PKI-587 50mg A11079-50

Regular Price: $460.00

Special Price: $391.00

PKI-587 100mg A11079-100

Regular Price: $860.00

Special Price: $731.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

PKI-587 is a highly potent PI3K/mTOR kinase inhibitor that inhibits PI3K-α,β,γ, δ isoforms and mTOR with IC50 of 0.4, 6.0, 5.4, 6.0 and 1.6 nM respectively.

PKI-587 ( Gedatolisib )

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Chemical Information

Catalog Num A11079
Actions Inhibitor
M. Wt 615.7
Formula C32H41N9O4
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1197160-78-3
Synonyms PKI587, Gedatolisib
SMILES code CN(C)C1CCN(CC1)C(=O)C2=CC=C(C=C2)NC(=O)NC3=CC=C(C=C3)C4=NC(=NC(=N4)N5CCOCC5)N6CCOCC6
Chemical Name 1-(4-(4-(Dimethylamino)piperidine-1-carbonyl)phenyl)-3-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)urea

Biological Activity

Description
PKI-587 is a highly potent PI3K/mTOR kinase inhibitor that inhibits PI3K-α,β,γ, δ isoforms and mTOR with IC50 of 0.4, 6.0, 5.4, 6.0 and 1.6 nM respectively.
Targets
PI3Kα (Cell-free assay) mTOR (Cell-free assay) PI3Kγ (Cell-free assay)
0.4 nM1.6 nM5.4 nM

Solubility

Solubility (25°C)* In vitro DMSO 2 mg/mL (3.24 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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