PP121

Anniversary Sale 20% OFF

PI3K Inhibitor

0 Customer Reviews
Catalog No. A11207

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
PP121 10mg A11207-10

Regular Price: $80.00

Special Price: $64.00

PP121 25mg A11207-25

Regular Price: $160.00

Special Price: $128.00

PP121 50mg A11207-50

Regular Price: $280.00

Special Price: $224.00

PP121 100mg A11207-100

Regular Price: $450.00

Special Price: $360.00

PP121 10mM * 1mL in DMSO A11207-10mM-D

Regular Price: $85.00

Special Price: $68.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

PP121 is a dual inhibitor of receptor tyrosine kinases (RTKs) (IC50 < 0.02 μM for Abl, Src, VEGFR-2 and PDGFR) and PI 3-K family kinases (IC50 < 0.06 μM for p110α, DNA-PK and mTOR).

PP121

Double click on above image to view full picture

Zoom Out
Zoom In

More Views

Publications citing Adooq Products

Chemical Information

Catalog Num A11207
Actions Inhibitor
M. Wt 319.36
Formula C17H17N7
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1092788-83-4
Synonyms PP-121
SMILES code C1CCC(C1)N2C3=C(C(=N2)C4=CN=C5C(=C4)C=CN5)C(=NC=N3)N
Chemical Name 1-Cyclopentyl-3-(1H-pyrrolo[2,3-b]p yridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Biological Activity

Description
PP121 is a dual inhibitor of receptor tyrosine kinases (RTKs) (IC50 < 0.02 μM for Abl, Src, VEGFR-2 and PDGFR) and PI 3-K family kinases (IC50 < 0.06 μM for p110α, DNA-PK and mTOR).
Targets
Target Value
PDGFRIC50: 2nM
HckIC50: 8nM
VEGFRIC50: 12nM
mTORIC50: 13nM
SrcIC50: 14nM
AblIC50: 18nM
p110αIC50: 52nM
DNA-PKIC50: 60nM
p110δIC50: 150nM
EphB4IC50: 190nM
EGFRIC50: 260nM
p110γIC50: 1.1μM
p110βIC50: 1.4μM

Solubility

Solubility (25°C)* In vitro DMSO 64 mg/mL (200.4 mM)
Water <1 mg/mL (<1 mM)
Ethanol 2 mg/mL (6.26 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Ordering online

To place an order online, simply browse to the product you are interested in and click on the 'Add to Cart' button. To complete this process, you will need to confirm the size and quantity of the products that you require.

To complete an order you will need to register using our simple online registration process. We do not share your contact details with any third parties.

When you are ready to check out simply enter your PO number to complete the ordering process. Please ensure that you send us a copy of your PO by fax or email afterwards.  We will then liaise with you or your purchasing department to confirm the order.

Found your products but not ready to order?

Why not use our WishList feature to store lists of products? This convenient feature allows you to manage lists, append notes to products and share lists with co-workers or colleagues.

Ordering offline

You can email or fax us your purchase order and we will place the order for you. You can also phone us to place the order.  Our contact details are:

We require the following information to process your order:
  • The catalog number for each product. 
  • Your email address or fax number. 
  • Your name and telephone number. 
  • Shipping address and billing address.
  • Purchase order numbers.

Product Tags

Use spaces to separate tags. Use single quotes (') for phrases.


Keywords:buy PP121 | PP121 Supplier | purchase PP121 | PP121 cost | PP121 manufacturer | order PP121 | PP121 distributor | buy 1092788-83-4| 1092788-83-4 Supplier | purchase 1092788-83-4 | 1092788-83-4 cost | 1092788-83-4 manufacturer | order 1092788-83-4 | 1092788-83-4 distributor