PP242 (Torkinib)
PP242 is a potent and selective mTOR inhibitor in both mTORC1 and mTORC2.
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Adooq's PP242 (Torkinib) has been cited by 4 publications
- Kohei Maruyama, .et al. , NPJ Precis Oncol, 2025, Jan 6;9(1):4 PMID: 39762482
- Nobuyuki Kondo, .et al. , JCI Insight, 2023, Dec 22;8(24):e173688 PMID: 37917191
- Hiroshi Fukamachi, .et al. , J Exp Clin Cancer Res, 2019, 38:127 PMID: 30866995
- Fuse MJ, .et al. , Mol Cancer Ther, 2017, Oct;16(10):2130-2143 PMID: 28751539
Biological Activity
| Description | PP242 is a potent and selective mTOR inhibitor in both mTORC1 and mTORC2. | ||
|---|---|---|---|
| Targets |
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Product Information
| Catalog Num | A10746 |
|---|---|
| Formula | C16H16N6O |
| Molecular Weight | 308.3 |
| CAS Number | 1092351-67-1 |
| SMILES | CC(C)N1C2=C(/C(=C\3/C=C4C=C(C=CC4=N3)O)/N1)C(=NC=N2)N |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Solubility
| In vitro (25°C) | DMSO | 57 mg/mL (184.86 mM) | |
| Water | Insoluble | ||
| Ethanol | 17 mg/mL (55.13 mM) | ||
| In vivo | 2% DMSO+30% PEG 300+5% Tween 80+ddH2O | 4 mg/mL | |
| * <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. | |||
Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 32.44 mL | 162.18 mL | 324.36 mL |
| 0.5 mM | 6.49 mL | 32.44 mL | 64.87 mL |
| 1 mM | 3.24 mL | 16.22 mL | 32.44 mL |
| 5 mM | 0.65 mL | 3.24 mL | 6.49 mL |
Useful Calculator
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
Please check COA/MSDS for correct molecular weight.
Calculate the dilution required to prepare a stock solution.This equation is commonly abbreviated as: C1V1 = C2V2
