PP242

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mTOR Inhibitor

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Catalog No. A10746

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
PP242 5mg A10746-5

Regular Price: $50.00

Special Price: $42.50

PP242 10mg A10746-10

Regular Price: $70.00

Special Price: $59.50

PP242 50mg A10746-50

Regular Price: $170.00

Special Price: $144.50

PP242 100mg A10746-100

Regular Price: $310.00

Special Price: $263.50

PP242 10mM * 1mL in DMSO A10746-10mM-D

Regular Price: $50.00

Special Price: $42.50

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

PP242 is a potent and selective mTOR inhibitor in both mTORC1 and mTORC2.

PP242

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Chemical Information

Catalog Num A10746
Actions Inhibitor
M. Wt 308.3
Formula C16H16N6O
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1092351-67-1
Synonyms PP-242
SMILES code CC(C)N1C2=C(/C(=C\3/C=C4C=C(C=CC4=N3)O)/N1)C(=NC=N2)N
Chemical Name 2-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol

Biological Activity

Description
PP242 is a potent and selective mTOR inhibitor in both mTORC1 and mTORC2.
Targets
Target Value
mTORIC50: 8nM
p110δIC50: 0.10μM
DNA-PKIC50: 0.41μM
PDGFRIC50: 0.41μM
HckIC50: 1.2μM
p110γIC50: 1.3μM
SrcIC50: 1.4μM
VEGFR2IC50: 1.5μM
p110αIC50: 2.0μM
p110βIC50: 2.2μM
EphB4IC50: 3.4μM
AblIC50: 3.6μM
EGFRIC50: 4.4μM
Src(T338I)IC50: 5.1μM

Solubility

Solubility (25°C) * In vitro DMSO 62 mg/mL (201.07 mM)
Water <1 mg/mL (<1 mM)
Ethanol 18 mg/mL (58.37 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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