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PR-619

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DUB inhibitor

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Catalog No. A13190

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
PR-619 5mg A13190-5

Regular Price: $40.00

Special Price: $32.00

PR-619 10mg A13190-10

Regular Price: $70.00

Special Price: $56.00

PR-619 25mg A13190-25

Regular Price: $100.00

Special Price: $80.00

PR-619 50mg A13190-50

Regular Price: $150.00

Special Price: $120.00

PR-619 10mM * 1mL in DMSO A13190-10mM-D

Regular Price: $80.00

Special Price: $64.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

PR-619 is a cell-permeable, reversible, and broad-spectrum inhibitor of the deubiquitinylating enzymes (DUBs).

PR-619

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Chemical Information

Catalog Num A13190
Actions Inhibitor
M. Wt 223.28
Formula C7H5N5S2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 2645-32-1
Synonyms PR619, PR 619
SMILES code C1=C(C(=NC(=C1SC#N)N)N)SC#N
Chemical Name 2,6-Diaminopyridine-3,5-bis(thiocyanate), 3,5-Dithiocyanatopyridine-2,6-diamine

Biological Activity

Description
PR-619 is a cell-permeable, reversible, and broad-spectrum inhibitor of the deubiquitinylating enzymes (DUBs).
Targets
Target Value
JOSD2EC50: 1.17μM
SENP6coreEC50: 2.37μM
UCH-L3EC50: 2.95μM
USP4EC50: 3.93μM
USP8EC50: 4.90μM
DEN1EC50: 4.98μM
USP20EC50: 5.10μM
USP28EC50: 6.24μM
USP7EC50: 6.86μM
USP2coreEC50: 7.20μM
USP15EC50: 8.23μM
USP5EC50: 8.61μM
USP47EC50: 8.87μM
UCH-L5EC50: 9.26μM
UCH-L1EC50: 12.8μM
PlproEC50: 14.2μM
PLA2EC50: >50μM
Calpain1EC50: >50μM
CT-LEC50: >50μM
CathepsinDEC50: >50μM
MMP13EC50: >50μM
TrypsinEC50: >50μM

Solubility

Solubility (25°C)* In vitro DMSO 45 mg/mL (201.54 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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