Ubiquitin

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    COH000

    Catalog No. A17122
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    SUMO E1 Inhibitor
    COH000 is a highly specific covalent allosteric SUMO E1 inhibitor with an IC50 of 0.2 μM for SUMOylation in vitro. Learn More
  1. N106

    Catalog No. A16183
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    SUMO-activating enzyme activator
    N106, activator of SUMO-activating enzyme, E1 ligase. Increases SERCA2a SUMOylation and activity, and enhances contractility in rat cardiomyocytes in vitro. Learn More
  2. 2-D08

    Catalog No. A16852
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    SUMO inhibitor
    2-D08 is a cell permeable, mechanistically unique inhibitor of protein sumoylation. It is also inhibits Axl, IRAK4, ROS1, MLK4, GSK3β, RET, KDR and PI3Kα with IC50 values of 0.49, 3.9, 5.3, 9.8, 11, 11, 17 and 35 nM respectively in biochemical assays. Learn More
  3. PYR-41

    Catalog No. A13254
    Ubiquitin E1 Inhibitor
    PYR-41 is a cell-permeable, irreversible ubiquitin-activating enzyme (E1) inhibitor (IC50 < 10 μM). Learn More
  4. TZ9

    Catalog No. A12811
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    Rad6 Ubiquitin Inhibitor
    TZ9 is a novel inhibitor of Rad6 ubiquitin conjugating enzyme(E2 enzyme); inhibits MDA-MB-231 cell proliferation with IC50 of ~6 uM. Learn More
  5. Bay 11-7821

    Catalog No. A11957
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    E2 ubiquitin conjugating enzyme inhibitor
    Bay 11-7821 is an irreversible inhibitor of TNF-α-stimulated IκBα phosphorylation. Learn More
  6. NSC697923

    Catalog No. A14068
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    E2 conjugating inhibitor
    NSC697923 is a cell-permeable and selective inhibitor of the Ub-conjugating enzyme (E2) complex Ubc13-Uev1A. Learn More
  7. SMER-3

    Catalog No. A13253
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    Ubiquitin E3 Ligase Inhibitor
    SMER3 is a selective inhibitor of a yeast SCF family E3 ubiquitin ligase (SCFMet30) in vitro and in vivo. Induces the expression of MET genes; blocks cell proliferation. Learn More
  8. HLI 373

    Catalog No. A15347
    HDM2 inhibitor
    HLI 373 is an inhibitor of Hdm2 ubiquitin ligase (E3) which blocks Hdm2-mediated ubiquitylation, proteasomal degradation of p53 and activates p53-dependent transcription. Learn More
  9. HLI-98C

    Catalog No. A13654
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    Hdm2 ubiquitin ligase Inhibitor
    HLI-98C, an analog, indeed inhibited Mdm2 E3 ligase activity. Learn More
  10. PRT 4165

    Catalog No. A15453
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    Bmi1/Ring1A inhibitor
    PRT 4165 is an inhibitor of Bmi1/Ring1A, subunits of the polycomb repressive complex 1 (PRC1). It prevents Bmi1/Ring1A-mediated ubiquitination and drug-induced degradation of topoisomerase 2alpha. Learn More
  11. TAME

    Catalog No. A10884
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    APC/C inhibitor
    TAME is a small molecule anaphase-promoting complex/cyclosome (APC) inhibitor with an IC50 of 12 μM. Learn More
  12. Thalidomide

    Catalog No. A10924
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    E3 ubiquitin ligase inhibitor
    Thalidomide can directly inhibit angiogenesis induced by bFGF or VEGF in vivo. Learn More
  13. Avadomide (CC-122)

    Catalog No. A16854
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    E3 Ligase inhibitor
    Avadomide(CC-122), a new chemical entity termed pleiotropic pathway modifier, is a novel agent for Diffuse large B-cell lymphoma(DLBCL) with antitumor and immunomodulatory activity. Its molecular target is the protein cereblon (CRBN), a substrate receptor of the cullin ring E3 ubiquitin ligase complex CRL4CRBN. Learn More
  14. DUBs-IN-2

    Catalog No. A12842
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    USP7/USP8 inhibitor
    DUBs-IN-2 is a potent deubiquitinase enzyme inhibitor with IC50s of 7.2 uM/0.93 uM for USP7/USP8 respectively. Learn More
  15. GNE-6640

    Catalog No. A16883
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    USP7 inhibitor
    GNE-6640 is a novel selective USP7 inhibitor, inducing tumor cell death. GNE-6640 enhances cytotoxicity with chemotherapeutic agents and targeted compounds, including PIM kinase inhibitors. Learn More
  16. USP7-IN-1

    Catalog No. A12813
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    USP7 inhibitor
    USP7-IN-1 is a novel selective and reversible inhibitor of USP7 with IC50 of 33 uM; less or no inhibition on USP5, USP8, Uch-L1, Uch-L3 and Caspase(IC50>200 uM); HCT116 cell viability GI50 is 67 uM. Learn More
  17. SJB3-019A

    Catalog No. A12822
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    USP1 inhibitor
    SJB3-019A is a potent and novel usp1 inhibitor. SJB3-019A (IC50 = 0.0781 uM) was 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells. Learn More
  18. VLX1570

    Catalog No. A16853
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    DUB inhibitor
    VLX1570 is a competitive inhibitor of proteasome DUB activity, with an IC50 of ~10?μM in vitro. Learn More
  19. DUBs-IN-1

    Catalog No. A12827
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    USP7/USP8 inhibitor
    DUBs-IN-1 is a potent deubiquitinase enzyme inhibitor with IC50s of 18 uM/0.71 uM for USP7/USP8 respectively. Learn More
  20. DUBs-IN-3

    Catalog No. A12830
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    USP7/USP8 inhibitor
    DUBs-IN-3 is a potent deubiquitinase enzyme inhibitor with IC50s of 3.1 uM for USP8; >30 fold selectivity over USP7 (IC50 > 100 uM). Learn More
  21. WP1130 (Degrasyn)

    Catalog No. A10988
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    DUB/Bcr/ABL Inhibitor
    WP1130 (Degrasyn) is a novel selective small molecular deubiquitinase inhibitor and a Bcr/Abl destruction pathway activator that specifically and rapidly down-regulates both wild-type and mutant Bcr/Abl protein without affecting bcr/abl gene expression in chronic myelogenous leukemia (CML) cells. Learn More
  22. PR-619

    Catalog No. A13190
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    DUB inhibitor
    PR-619 is a cell-permeable, reversible, and broad-spectrum inhibitor of the deubiquitinylating enzymes (DUBs). Learn More
  23. P 22077

    Catalog No. A12933
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    USP7 inhibitor
    P 22077 is a cell-permeable inhibitor of the ubiquitin-specific protease (IC?? = 8.6 μM) and the closely related deubiquitinase (DUB) USP47. Learn More
  24. LDN-57444

    Catalog No. A12715
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    UCH-L1 Inhibitor
    LDN-57444 is a potent, reversible, competitive and active site-directed inhibitor of UCHL1. Learn More
  25. P005091

    Catalog No. A13277
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    DUB/USP7 Inhibitor
    P005091 is a selective inhibitor of ubiquitin-specific protease (USP) 7 (IC50 = 4.2 uM). Learn More
  26. IU1

    Catalog No. A13209
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    Usp14 inhibitor
    IU1 is a selective inhibitor of Usp14. It inhibits the catalytic activity of proteasome-associated Usp14 in vitro (IC50 < 4 uM). Learn More
  27. HBX 41108

    Catalog No. A13352
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    USP 7 inhibitor
    HBX 41108 is an inhibitor of ubiquitin-specific protease (USP) 7 activity (IC50 = 424 nM). Learn More
  28. ML-323

    Catalog No. A14030
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    USP1-UAF1 inhibitor
    ML323 is a selective and highly potent USP1-UAF1 inhibitor links deubiquitination to DNA damage responses. Learn More
  29. SJB2-043

    Catalog No. A15238
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    USP1 Inhibitor
    SJB2-043 is one of analogs/derivatives of C527, which is a novel and potent USP1 (ubiquitin-specific protease 1) inhibitor. Learn More
  30. Vialinin A

    Catalog No. A15321
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    USP4 Inhibitor
    Vialinin A is a terphenyl compound originally isolated from the fungi T. terrestris and T. vialis. Learn More
  31. b-AP15 (NSC 687852)

    Catalog No. A15391
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    DUB inhibitor
    NSC 687852 is an inhibitor of ubiquitin-specific-processing protease 14 (USP14) and ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5), two proteasome-associated DUBs. Learn More
  32. DBeq

    Catalog No. A12736
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    p97 ATPase inhibitor
    Dbeq is a selective and reversible inhibitor of p97 ATPase (IC50 = 1.5 uM). Learn More
  33. NMS-873

    Catalog No. A12377
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    p97 inhibitor
    NMS-873 is a potent and specific small molecule allosteric inhibitor of the ATPase VCP/p97 (IC50 ~0.03 uM), identified by a high-throughput screening. Learn More
  34. ML241

    Catalog No. A15985
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    p97 ATPase inhibitor
    ML241 is a potent and selective inhibitors of p97 ATPase. ML241 inhibit p97 ATPase with IC(50) values of 100 nM. Learn More

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