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TAK-981
Catalog No. A20002 SUMO inhibitorTAK-981 is a first in class and selective inhibitor of the SUMOylation enzymatic cascade, with potential immune-activating and antineoplastic activities. Learn More -
PYR-41
Catalog No. A13254 Ubiquitin E1 InhibitorPYR-41 is a cell-permeable, irreversible ubiquitin-activating enzyme (E1) inhibitor (IC50 < 10 μM). Learn More -
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COH000
Catalog No. A17122 SUMO E1 InhibitorCOH000 is a highly specific covalent allosteric SUMO E1 inhibitor with an IC50 of 0.2 μM for SUMOylation in vitro. Learn More -
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2-D08
Catalog No. A16852 SUMO inhibitor2-D08 is a cell permeable, mechanistically unique inhibitor of protein sumoylation. It is also inhibits Axl, IRAK4, ROS1, MLK4, GSK3β, RET, KDR and PI3Kα with IC50 values of 0.49, 3.9, 5.3, 9.8, 11, 11, 17 and 35 nM respectively in biochemical assays. Learn More -
N106
Catalog No. A16183 SUMO-activating enzyme activatorN106, activator of SUMO-activating enzyme, E1 ligase. Increases SERCA2a SUMOylation and activity, and enhances contractility in rat cardiomyocytes in vitro. Learn More -
TZ9
Catalog No. A12811 Rad6 Ubiquitin InhibitorTZ9 is a novel inhibitor of Rad6 ubiquitin conjugating enzyme(E2 enzyme); inhibits MDA-MB-231 cell proliferation with IC50 of ~6 uM. Learn More -
Bay 11-7821
Catalog No. A11957 E2 ubiquitin conjugating enzyme inhibitorBay 11-7821 is an irreversible inhibitor of TNF-α-stimulated IκBα phosphorylation. Learn More -
NSC697923
Catalog No. A14068 E2 conjugating inhibitorNSC697923 is a cell-permeable and selective inhibitor of the Ub-conjugating enzyme (E2) complex Ubc13-Uev1A. Learn More -
Thalidomide
Catalog No. A10924 E3 ubiquitin ligase inhibitorThalidomide can directly inhibit angiogenesis induced by bFGF or VEGF in vivo. Learn More -
PRT 4165
Catalog No. A15453 Bmi1/Ring1A inhibitorPRT 4165 is an inhibitor of Bmi1/Ring1A, subunits of the polycomb repressive complex 1 (PRC1). It prevents Bmi1/Ring1A-mediated ubiquitination and drug-induced degradation of topoisomerase 2alpha. Learn More -
HLI 373
Catalog No. A15347 HDM2 inhibitorHLI 373 is an inhibitor of Hdm2 ubiquitin ligase (E3) which blocks Hdm2-mediated ubiquitylation, proteasomal degradation of p53 and activates p53-dependent transcription. Learn More -
HLI-98C
Catalog No. A13654 Hdm2 ubiquitin ligase InhibitorHLI-98C, an analog, indeed inhibited Mdm2 E3 ligase activity. Learn More -
Avadomide (CC-122)
Catalog No. A16854 E3 Ligase inhibitorAvadomide(CC-122), a new chemical entity termed pleiotropic pathway modifier, is a novel agent for Diffuse large B-cell lymphoma(DLBCL) with antitumor and immunomodulatory activity. Its molecular target is the protein cereblon (CRBN), a substrate receptor of the cullin ring E3 ubiquitin ligase complex CRL4CRBN. Learn More -
SMER-3
Catalog No. A13253 Ubiquitin E3 Ligase InhibitorSMER3 is a selective inhibitor of a yeast SCF family E3 ubiquitin ligase (SCFMet30) in vitro and in vivo. Induces the expression of MET genes; blocks cell proliferation. Learn More -
TAME
Catalog No. A10884 APC/C inhibitorTAME is a small molecule anaphase-promoting complex/cyclosome (APC) inhibitor with an IC50 of 12 μM. Learn More -
b-AP15 (NSC 687852)
Catalog No. A15391 DUB inhibitorNSC 687852 is an inhibitor of ubiquitin-specific-processing protease 14 (USP14) and ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5), two proteasome-associated DUBs. Learn More -
DUBs-IN-2
Catalog No. A12842 USP7/USP8 inhibitorDUBs-IN-2 is a potent deubiquitinase enzyme inhibitor with IC50s of 7.2 uM/0.93 uM for USP7/USP8 respectively. Learn More -
VLX1570
Catalog No. A16853 DUB inhibitorVLX1570 is a competitive inhibitor of proteasome DUB activity, with an IC50 of ~10?μM in vitro. Learn More -
DUBs-IN-3
Catalog No. A12830 USP7/USP8 inhibitorDUBs-IN-3 is a potent deubiquitinase enzyme inhibitor with IC50s of 3.1 uM for USP8; >30 fold selectivity over USP7 (IC50 > 100 uM). Learn More -
DUBs-IN-1
Catalog No. A12827 USP7/USP8 inhibitorDUBs-IN-1 is a potent deubiquitinase enzyme inhibitor with IC50s of 18 uM/0.71 uM for USP7/USP8 respectively. Learn More -
GNE-6640
Catalog No. A16883 USP7 inhibitorGNE-6640 is a novel selective USP7 inhibitor, inducing tumor cell death. GNE-6640 enhances cytotoxicity with chemotherapeutic agents and targeted compounds, including PIM kinase inhibitors. Learn More -
SJB3-019A
Catalog No. A12822 USP1 inhibitorSJB3-019A is a potent and novel usp1 inhibitor. SJB3-019A (IC50 = 0.0781 uM) was 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells. Learn More -
USP7-IN-1
Catalog No. A12813 USP7 inhibitorUSP7-IN-1 is a novel selective and reversible inhibitor of USP7 with IC50 of 33 uM; less or no inhibition on USP5, USP8, Uch-L1, Uch-L3 and Caspase(IC50>200 uM); HCT116 cell viability GI50 is 67 uM. Learn More -
WP1130 (Degrasyn)
Catalog No. A10988 DUB/Bcr/ABL InhibitorWP1130 (Degrasyn) is a novel selective small molecular deubiquitinase inhibitor and a Bcr/Abl destruction pathway activator that specifically and rapidly down-regulates both wild-type and mutant Bcr/Abl protein without affecting bcr/abl gene expression in chronic myelogenous leukemia (CML) cells. Learn More -
Vialinin A
Catalog No. A15321 USP4 InhibitorVialinin A is a terphenyl compound originally isolated from the fungi T. terrestris and T. vialis. Learn More -
SJB2-043
Catalog No. A15238 USP1 InhibitorSJB2-043 is one of analogs/derivatives of C527, which is a novel and potent USP1 (ubiquitin-specific protease 1) inhibitor. Learn More -
ML-323
Catalog No. A14030 USP1-UAF1 inhibitorML323 is a selective and highly potent USP1-UAF1 inhibitor links deubiquitination to DNA damage responses. Learn More -
HBX 41108
Catalog No. A13352 USP 7 inhibitorHBX 41108 is an inhibitor of ubiquitin-specific protease (USP) 7 activity (IC50 = 424 nM). Learn More -
IU1
Catalog No. A13209 Usp14 inhibitorIU1 is a selective inhibitor of Usp14. It inhibits the catalytic activity of proteasome-associated Usp14 in vitro (IC50 < 4 uM). Learn More -
P005091
Catalog No. A13277 DUB/USP7 InhibitorP005091 is a selective inhibitor of ubiquitin-specific protease (USP) 7 (IC50 = 4.2 uM). Learn More -
LDN-57444
Catalog No. A12715 UCH-L1 InhibitorLDN-57444 is a potent, reversible, competitive and active site-directed inhibitor of UCHL1. Learn More -
P 22077
Catalog No. A12933 USP7 inhibitorP 22077 is a cell-permeable inhibitor of the ubiquitin-specific protease (IC?? = 8.6 μM) and the closely related deubiquitinase (DUB) USP47. Learn More -
PR-619
Catalog No. A13190 DUB inhibitorPR-619 is a cell-permeable, reversible, and broad-spectrum inhibitor of the deubiquitinylating enzymes (DUBs). Learn More -
CB5083
Catalog No. A15827 p97 inhibitorCB-5083 is a novel first in class, potent orally bio-available p97 inhibitor that disrupts cellular protein homeostasis and demonstrates anti-tumor activity in solid and hematological models . Learn More -
MSC1094308
Catalog No. A19120 p97/VPS4B inhibitorMSC1094308 is a reversible and allosteric inhibitor of the type II AAA ATPase human ubiquitin-directed unfoldase (VCP)/p97 and the type I AAA ATPase VPS4B, with IC50 values of 0.71 μM and 7.2 μM for VPS4B and p97, respectively. Learn More -
NMS-859
Catalog No. A21965 VCP (p97) inhibitorNMS-859 is a potent, covalent VCP (p97) inhibitor, with IC50s of 0.37 and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively. Learn More -
ML241
Catalog No. A15985 p97 ATPase inhibitorML241 is a potent and selective inhibitors of p97 ATPase. ML241 inhibit p97 ATPase with IC(50) values of 100 nM. Learn More -
DBeq
Catalog No. A12736 p97 ATPase inhibitorDbeq is a selective and reversible inhibitor of p97 ATPase (IC50 = 1.5 uM). Learn More -
NMS-873
Catalog No. A12377 p97 inhibitorNMS-873 is a potent and specific small molecule allosteric inhibitor of the ATPase VCP/p97 (IC50 ~0.03 uM), identified by a high-throughput screening. Learn More
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