Catalog No.
Product Name
Application
Product Information
Citations
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DUB/Bcr/ABL Inhibitor
WP1130 (Degrasyn) is a novel selective small molecular deubiquitinase inhibitor and a Bcr/Abl destruction pathway activator that specifically and rapidly down-regulates both wild-type and mutant Bcr/Abl protein without affecting bcr/abl gene expression in chronic myelogenous leukemia (CML) cells.- Kevin Bohm, .et al. , Arch Pharm (Weinheim), 2023, Jul;356(7):e2200661 PMID: 37196427
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DUB inhibitor
PR-619 is a cell-permeable, reversible, and broad-spectrum inhibitor of the deubiquitinylating enzymes (DUBs).- Anurag Rathore, .et al. , Sci Rep, 2020, 10: 5350 PMID: 32210344
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Usp14 inhibitor
IU1 is a selective inhibitor of Usp14. It inhibits the catalytic activity of proteasome-associated Usp14 in vitro (IC50 < 4 uM).- Kevin Bohm, .et al. , Arch Pharm (Weinheim), 2023, Jul;356(7):e2200661 PMID: 37196427
- Anurag Rathore, .et al. , Sci Rep, 2020, 10: 5350 PMID: 32210344
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USP 7 inhibitor
HBX 41108 is an inhibitor of ubiquitin-specific protease (USP) 7 activity (IC50 = 424 nM).- Kevin Bohm, .et al. , Arch Pharm (Weinheim), 2023, Jul;356(7):e2200661 PMID: 37196427
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USP1 Inhibitor
SJB2-043 is one of analogs/derivatives of C527, which is a novel and potent USP1 (ubiquitin-specific protease 1) inhibitor.- Kevin Bohm, .et al. , Arch Pharm (Weinheim), 2023, Jul;356(7):e2200661 PMID: 37196427
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USP4 Inhibitor
Vialinin A is a terphenyl compound originally isolated from the fungi T. terrestris and T. vialis. -
DUB inhibitor
NSC 687852 is an inhibitor of ubiquitin-specific-processing protease 14 (USP14) and ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5), two proteasome-associated DUBs.- Anurag Rathore, .et al. , Sci Rep, 2020, 10: 5350 PMID: 32210344
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SARS PLPro inhibitor
GRL0617 is a potent, selective and competitive noncovalent inhibitor of SARS PLPro, with an IC50 of 0.6 μM, and with a Ki of 0.49 μM.- GuanQun Liu, .et al. , Nat Microbiol, 2021, Apr;6(4):467-478 PMID: 33727702
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DUB inhibitor
EOAI3402143 is a deubiquitinase (DUB) inhibitor, which inhibits dose-dependently inhibits Usp9x/Usp24 and Usp5. -
USP2 inhibitor
ML364 is a selective ubiquitin specific peptidase 2 (USP2) inhibitor (IC50=1.1 μM) with anti-proliferative activity.- Kevin Bohm, .et al. , Arch Pharm (Weinheim), 2023, Jul;356(7):e2200661 PMID: 37196427
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USP7/USP47 inhibitor
USP7/USP47 inhibitor is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 μM and 1.0 μM, respectively. -
UCH-L3 inhibitor
TCID (4,5,6,7-Tetrachloroindan-1,3-dione) is a potent and selective inhibitor of neuronal ubiquitin C-terminal hydrolase UCH-L3, with an IC50 of 0.6 μM. It reduces ubiquitination of the glycine transporter GlyT2 in primary neurons from the brainstem and spinal cord, making it a valuable tool for studying neuronal ubiquitin regulation and glycinergic neurotransmission. -
USP7 PROTAC Degrader
U7D-1 is a first-in-class, potent, and selective PROTAC degrader of USP7 (ubiquitin-specific protease 7), with a DC₅₀ of 33 nM in RS4;11 cells. It exhibits anticancer activity and induces apoptosis in Jeko-1 cells, supporting its utility in cancer research targeting deubiquitinating enzymes. -
Cysteine Residues Modifier
N-Ethylmaleimide (NEM) is a potent chemical reagent that irreversibly alkylates free sulfhydryl groups, specifically targeting cysteine residues. This compound serves as an effective inhibitor of cysteine proteases and significantly affects phosphate transport in mitochondria. With an IC50 value of 6.3 μM, N-Ethylmaleimide is valuable for modifying cysteine residues in proteins and peptides, making it an essential tool in biochemical research and studies involving protein functionality and structure.
