QNZ (EVP4593)

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NF-κB inhibitor

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Catalog No. A12748

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
QNZ 5mg A12748-5

Regular Price: $50.00

Special Price: $42.50

QNZ 10mg A12748-10

Regular Price: $80.00

Special Price: $68.00

QNZ 25mg A12748-25

Regular Price: $150.00

Special Price: $127.50

QNZ 50mg A12748-50

Regular Price: $250.00

Special Price: $212.50

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

QNZ inhibits the activation of the transcription factor NF-κB and has been used to investigate NF-κB signaling.

QNZ (EVP4593)

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Chemical Information

Catalog Num A12748
Actions Inhibitor
M. Wt 356.4
Formula C22H20N4O
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 545380-34-5
Synonyms CAY10470, CAY 10470, CAY-10470
SMILES code C1=CC=C(C=C1)OC2=CC=C(C=C2)CCNC3=NC=NC4=C3C=C(C=C4)N
Chemical Name N4-?[2-?(4-?phenoxyphenyl)ethyl]-?4,?6-?quinazolinediamine

Biological Activity

Description
QNZ inhibits the activation of the transcription factor NF-κB and has been used to investigate NF-κB signaling.
Targets
TNF-α (Jurkat T cells) NF-κB (Jurkat T cells)
7 nM11 nM

Solubility

Solubility (25°C) * In vitro DMSO 5 mg/mL (14.02 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% hydroxyethyl cellulose 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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