TNF-α

Cat. No.

A10522

CAS No.

191732-72-6

Lenalidomide (CC-5013)

Synonyms: Revlimid; CC-5013

Lenalidomide is a derivative of thalidomide. In vitro, lenalidomide has three main activities: direct anti-tumor effect, inhibition of the micro environment support for tumor cells, and immunomodulatory role. It induces tumor cell apoptosis directly and indirectly by inhibition of bone marrow stromal cell support, by anti-angiogenic and anti-osteoclastogenic effects, and by immunomodulatory activity.

Cat. No.

A11974

CAS No.

6823-69-4

GW 4869

GW4869 is a cell permeable, selective inhibitor of N-SMase (neutral sphingomyelinase).

Cat. No.

A11973

CAS No.

4311-88-0

Necrostatin-1

Necrostatin-1 is an ATP-competitive, allosteric inhibitor of receptor-interacting protein kinase 1 (RIPK1) (EC50 = 182 nM).

Cat. No.

A12748

CAS No.

545380-34-5

QNZ (EVP4593)

Synonyms: CAY10470; EVP4593

QNZ inhibits the activation of the transcription factor NF-κB and has been used to investigate NF-κB signaling.

Cat. No.

A10743

CAS No.

19171-19-8

Pomalidomide (CC-4047)

Synonyms: Actimid; CC-4047

Pomalidomide is a derivative of thalidomide and acts as an immunomodulator.

Cat. No.

A10924

CAS No.

50-35-1

Thalidomide

Thalidomide can directly inhibit angiogenesis induced by bFGF or VEGF in vivo.

Cat. No.

A12009

CAS No.

185243-69-0

Etanercept

Etanercept, a dimeric fusion protein that binds TNF, acts as a TNF inhibitor.

Cat. No.

A12197

CAS No.

1021497-97-1

KR-33493

KR-33493 is a potent inhibitor of Fas-mediated cell death (FAF1).

Cat. No.

A12313

CAS No.

332420-90-3

C 87

C87 is a novel small-molecule TNFα inhibitor; potently inhibits TNFα-induced cytotoxicity with an IC50 of 8.73 μM.

Cat. No.

A12447

CAS No.

13419-46-0

DCVC

DCVC inhibits pathogen-stimulated TNF-α in human extra placental membranes in vitro.

Cat. No.

A15183

CAS No.

852391-19-6

Necrostatin 2

Synonyms: MTH-DL-Tryptophan; Necroptotic Inhibitor

Necrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM.

Cat. No.

A15327

CAS No.

852391-15-2

Necrostatin 2 racemate

Necrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM.

Cat. No.

A15328

CAS No.

852391-20-9

Necrostatin 2 S enantiomer

Necrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM.

Cat. No.

A15565

CAS No.

11021-14-0

Ginsenoside Rc

Synonyms: Panaxoside Rc

Ginsenoside Rc, isolated from Panax ginseng, may exert various activities including anti-cancer, anti-inflammatory, antiobesity, and anti-diabetic effects.

Cat. No.

A15607

CAS No.

17680-84-1

Homoplantaginin

Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia with antiinflammatory and antioxidant properties. Homoplantaginin could inhibit TNF-α and IL-6 mRNA expression, IKKβ and NF-κB phosphorylation.

Cat. No.

A15688

CAS No.

541-91-3

Muscone

Synonyms: Methylexaltone; 3-Methylcyclopentadecanone

Muscone, a TNF receptor inhibitor, is derived from the traditional Chinese medicine musk. It effectively inhibits NF-κB signaling and NLRP3 inflammasome activation, resulting in a significant reduction of inflammatory cytokines such as IL-1β, TNF-α, and IL-6. This compound is valuable in research focused on inflammation, cardiac function restoration, and improving survival rates in various pathological conditions.

Cat. No.

A16915

CAS No.

35730-78-0

Cynaropicrin

Cynaropicrin is a sesquiterpene lactone originally isolated from artichoke (C. scolymus) that has diverse biological activities. It inhibits the growth of SKOV3, LOX-IMVI, A549, MCF-7, HCT15, and PC-3 cancer cells (IC50s = 1.1-8.7 μg/ml).

Cat. No.

A17238

CAS No.

37854-59-4

Ro 08-2750

Ro 08-2750 is a potent and selective Nerve growth factor (NGF) inhibitor that binds the NGF dimer (KD ~ 1 μM).

Cat. No.

A18705

CAS No.

1358099-18-9

C25-140

C25-140, a first-in-class, fairly selective TRAF6-Ubc13 inhibitor, directly binds to TRAF6, and blocks the interaction of TRAF6 with Ubc13. C25-140 lowers TRAF6 activity, reduces NF-κB activation, and combats autoimmunity.

Cat. No.

A18773

CAS No.

2101765-81-3

DRI-C21045

DRI-C21045 is a potent and selective inhibitor of the CD40-CD40L costimulatory protein-protein interaction (PPI) with an IC50 of 0.17 µM.

Cat. No.

A19364

CAS No.

869998-49-2

SPD304

SPD304 is a selective TNF-α inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor.

Cat. No.

A19687

CAS No.

444287-49-4

TNF-α-IN-1

TNF-α-IN-1 is a TNF-α inhibitor extracted from patent US20030096841A1, compound example I-7.

Cat. No.

A19783

CAS No.

303997-35-5

R-7050

Synonyms: TNF-α Antagonist III

R-7050 (TNF-α Antagonist III) is a tumor necrosis factor receptor (TNFR) antagonist with greater selectivity toward TNFα.

Cat. No.

A20185

CAS No.

5786-54-9

Hispidol

Synonyms: (Z)-Hispidol

Hispidol ((Z)-Hispidol) is a potential therapeutic for inflammatory bowel disease; inhibits TNF-α induced adhesion of monocytes to colon epithelial cells with an IC50 of 0.50 µM.

Cat. No.

A20290

CAS No.

112924-45-5

Dexanabinol

Synonyms: HU-211

Dexanabinol exhibits not only the antioxidant and neuroprotective activities in brain but also anti-inflammatory activity by inhibiting NF-κB and decreasing cytokines such as TNFα and interleukin-6, which could ensure the integrity of BBB and reduce cell apoptosis and death.