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MEK inhibitor

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Catalog No. A11264

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Refametinib 10mg A11264-10

Regular Price: $90.00

Special Price: $72.00

Refametinib 25mg A11264-25

Regular Price: $180.00

Special Price: $144.00

Refametinib 50mg A11264-50

Regular Price: $300.00

Special Price: $240.00

Refametinib 10mM * 1mL in DMSO A11264-10mM-D

Regular Price: $111.00

Special Price: $88.80

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Refametinib is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively.


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Chemical Information

Catalog Num A11264
Actions Inhibitor
M. Wt 572.34
Formula C19H20F3IN2O5S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 923032-37-5
Synonyms BAY 869766,RDEA119, Bay 86-9766
SMILES code COC1=CC(=C(C(=C1NS(=O)(=O)C2(CC2)C[[email protected]@H](CO)O)NC3=C(C=C(C=C3)I)F)F)F
Chemical Name (S)-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide

Biological Activity

Refametinib is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively.
19 nM47 nM


Solubility (25°C)* In vitro DMSO 100 mg/mL (174.72 mM)
Water <1 mg/mL (<1 mM)
Ethanol 100 mg/mL (174.72 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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