RO5126766 (CH5126766)

Catalog No.: A14019
Raf/MEK dual inhibitor
RO5126766, also known as CH5126766, is a protein kinase inhibitor specific for the Raf and MEK mitogen-activated protein kinases (MAPKs) with potential anti-neoplastic activity.
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Product Name Price Stock Qty
RO5126766 5mg
$140.00
In stock
RO5126766 10mg
$220.00
In stock
RO5126766 25mg
$450.00
In stock
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Adooq Products cited in reputable paper
Adooq's RO5126766 (CH5126766) has been cited by 1 publications
  • Yuki Shimizu, .et al. , Cancer Lett, 2022, Sep 1;543 PMID: 35724767
  • Biological Activity
    Discription RO5126766, also known as CH5126766, is a protein kinase inhibitor specific for the Raf and MEK mitogen-activated protein kinases (MAPKs) with potential anti-neoplastic activity.
    Targets
    Target Value
    Product Information
    Catalog Num A14019
    Formula C21H18FN5O5S
    Molecular Weight 471.5
    CAS Number 946128-88-7
    SMILES CC1=C(C(=O)OC2=C1C=CC(=C2)OC3=NC=CC=N3)CC4=C(C(=NC=C4)NS(=O)(=O)NC)F
    Synonyms RO 5126766, RO-5126766, CH5126766, CH-5126766, CH 5126766.
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 93 mg/mL (197.26 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 5% DMSO+45% PEG 300+ddH2O 19 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 21.21 mL 106.04 mL 212.09 mL
    0.5 mM 4.24 mL 21.21 mL 42.42 mL
    1 mM 2.12 mL 10.6 mL 21.21 mL
    5 mM 0.42 mL 2.12 mL 4.24 mL
    Useful Calculator

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    This equation is commonly abbreviated as: C1V1 = C2V2

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