SANT-1

Catalog No.: A13095
Sonic hedgehog inhibitor
SANT-1 is a potent, cell-permeable inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (KD = 1.2 nM). Inhibits smoothened agonist effects with an IC50 of 20 nM (in Shh-LIGHT2 cells).
Grouped product items
Product Name Price Stock Qty
SANT-1 10mg
$81.00
In stock
SANT-1 25mg
$162.00
In stock
SANT-1 50mg
$243.00
In stock
SANT-1 100mg
$405.00
In stock
SANT-1 10mM * 1mL in DMSO
$96.00
In stock
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Biological Activity
Discription SANT-1 is a potent, cell-permeable inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (KD = 1.2 nM). Inhibits smoothened agonist effects with an IC50 of 20 nM (in Shh-LIGHT2 cells).
Targets
Target Value
Product Information
Catalog Num A13095
Formula C23H27N5
Molecular Weight 373.5
CAS Number 304909-07-7
SMILES CC1=C(C(=NN1C2=CC=CC=C2)C)/C=N/N3CCN(CC3)CC4=CC=CC=C4
Synonyms SANT 1, SANT1
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro DMSO 21 mg/mL (56.22 mM)
Water Insoluble
Ethanol 20 mg/mL (53.54 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.77 mL 133.87 mL 267.74 mL
0.5 mM 5.35 mL 26.77 mL 53.55 mL
1 mM 2.68 mL 13.39 mL 26.77 mL
5 mM 0.54 mL 2.68 mL 5.35 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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