Hedgehog

Cat. No.

A10258

CAS No.

879085-55-9

Vismodegib (GDC-0449)

Synonyms: GDC-0449

GDC-0449 (Vismodegib) is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM.

Cat. No.

A13252

CAS No.

500579-04-4

GANT61

Synonyms: NSC136476

GANT61 is an inhibitor for GLI1 as well as GLI2-induced transcription, inhibits hedgehog with IC50 of 5 μM, displays selectivity over other pathways, such as TNF and glucocorticoid receptor gene transactivation.

Cat. No.

A11480

CAS No.

483367-10-8

Purmorphamine

Purmorphamine is a 2,6,9-trisubstituted purine that promotes the differentiation of both human and mouse mesenchymal progenitor cells into osteoblasts.

Cat. No.

A10249

CAS No.

4449-51-8

Cyclopamine

Synonyms: 11-deoxojervine

Cyclopamine is a Smo or hedgehog signaling pathway inhibitor.

Cat. No.

A11048

CAS No.

1258861-20-9

Taladegib (LY2940680)

Synonyms: LY-2940680

LY2940680 has been shown to affect a cancer cell signaling pathway initiated by the Hedgehog (Hh) protein.

Cat. No.

A11351

CAS No.

1186231-83-3

TAK-441

TAK-441 is a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor.

Cat. No.

A11442

CAS No.

64048-12-0

GANT 58

GANT 58 is a potent Gli antagonist that inhibits GLI1-induced transcription with IC50 of 5 μM.

Cat. No.

A12418

CAS No.

496794-70-8

HhAntag

HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway.

Cat. No.

A12920

CAS No.

612542-14-0

Hh-Ag1.5

Hh-Ag1.5 is one of the most potent and selective small-molecule agonists of the Hedgehog pathway, targeting Smoothened (Smo) with an EC50 ~1 nM.

Cat. No.

A12925

CAS No.

315703-52-7

JK 184

JK184 is potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC50 = 30 nM).

Cat. No.

A13095

CAS No.

304909-07-7

SANT-1

SANT-1 is a potent, cell-permeable inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (KD = 1.2 nM). Inhibits smoothened agonist effects with an IC50 of 20 nM (in Shh-LIGHT2 cells).

Cat. No.

A16111

CAS No.

935273-79-3

MK-4101

MK-4101 is a potent and selective inhibitor of the Hedgehog Pathway.

Cat. No.

A16229

CAS No.

1043797-53-0

RU-SKI 43

Synonyms: Hhat Inhibitor

RU-SKI 43 is a small molecule inhibitor of Hhat(Hedgehog acyltransferase), the enzyme responsible for the attachment of palmitate onto Shh.

Cat. No.

A16349

CAS No.

302803-72-1

HPI-4

Synonyms: Ciliobrevin A

HPI-4 is a hedgehog (Hh) signaling pathway inhibitor with median inhibitory concentration (IC50) less than 10 μM.

Cat. No.

A16606

CAS No.

31431-39-7

Mebendazole

Mebendazole is a highly effective, broad-spectrum antihelmintic indicated for the treatment of nematode infestations; has been found as a hedgehog inhibitor.

Cat. No.

A18662

CAS No.

2222768-84-3

Dynarrestin

Dynarrestin is a aminothiazole inhibitor of cytoplasmic dyneins 1 and 2.

Cat. No.

A20195

CAS No.

3039-71-2

U18666A

U18666A, a cell permeable drug, is a cholesterol synthesis and transport inhibitor.

Cat. No.

A24864

CAS No.

300833-95-8

GSA-10

GSA-10 is a potent agonist of the smooth (Smo) receptor, playing a crucial role in mediating Hedgehog (Hh) signaling pathways. This compound exhibits significant osteogenic activity and is valuable in regenerative medicine and research on cancer pathologies. Additionally, GSA-10 can be utilized in studies focused on adipogenesis and fat development, making it a versatile tool in biological research.

Cat. No.

A24870

CAS No.

937807-66-4

Neurodazine

Neurodazine is a neurogenesis inducer that promotes the differentiation of pluripotent cells into neuronal lineages. This compound activates the Wnt and Shh signaling pathways, facilitating neural development and potentially improving neuroregeneration applications. Neurodazine is suitable for research in developmental biology, neuroscience, and regenerative medicine.

Cat. No.

A31222

CAS No.

334998-36-6

CUR61414

CUR61414 is a potent inhibitor of the Hedgehog signaling pathway, specifically targeting the Smoothened (Smo) protein with a Ki value of 44 nM. This small-molecule aminoproline derivative demonstrates selective activity, inducing apoptosis in cancer cells while sparing adjacent non-tumor cells. CUR61414 is valuable for research applications focused on cancer biology and therapeutic strategies aimed at manipulating Hedgehog pathway activity.

Cat. No.

A32624

CAS No.

2170347-69-8

TPB15

TPB15 is a potent inhibitor of Hedgehog (Hh) signaling, specifically targeting Smoothened (Smo). This compound effectively induces cell cycle arrest and apoptosis in MDA-MB-468 breast cancer cells by blocking Smo translocation into cilia and reducing the expression of Smo protein and mRNA. Additionally, TPB15 downregulates glioma-associated oncogene 1 (Gli1), a key downstream regulator. TPB15 demonstrates significant anti-tumor activity with a favorable toxicity profile, making it a valuable tool for cancer research focused on Hedgehog pathway modulation.

Cat. No.

A40553

CAS No.

438488-95-0

Hedgehog IN-9

Hedgehog IN-9 is a potent Hedgehog inhibitor that primarily targets the inhibition of GLI1 expression. It has been shown to enhance BRD2 protein levels in cells and effectively inhibit the growth of medulloblastoma spheroid cells. Additionally, Hedgehog IN-9 can be utilized for the synthesis of photoaffinity labeling probes, making it a valuable tool in cancer research and related biochemical applications.

Cat. No.

A44257

CAS No.

1132653-79-2

Robotnikinin

Robotnikinin is a small molecule inhibitor targeting the Sonic Hedgehog (Shh) signaling pathway by binding to and inhibiting its upstream activator, Smoothened (Smo). This compound demonstrates significant biological activity in modulating Shh-related cellular processes, making it a valuable tool for studying developmental biology and cancer research. Its application may also extend to exploring therapeutic strategies in diseases associated with aberrant Shh signaling.

Cat. No.

A44258

CAS No.

946002-48-8

Hedgehog agonist 1

Hedgehog agonist 1 is a potent Hedgehog (Hh) pathway activator with an EC50 of 0.3 nM. This compound facilitates the modulation of Hh signaling, making it useful for investigating its role in stroke and various neurological disorders. Its ability to activate Hh signaling pathways may provide valuable insights into therapeutic strategies for neurodegenerative conditions.

Cat. No.

A44259

CAS No.

599150-20-6

Hh Pathway-IN-1

Hh Pathway-IN-1 is a potent inhibitor of the Hedgehog (Hh) signaling pathway, acting primarily as a Gli antagonist. With an IC50 value of 1.1 µM in C3H10T1/2 cells, it demonstrates significant inhibition of Hh pathway functionality while sparing Wnt signaling. Hh Pathway-IN-1 exhibits anti-proliferative effects and reduces GLI1 mRNA expression, contributing to its efficacy in inhibiting colony formation in a dose-dependent manner. This compound is valuable for research in developmental biology and cancer therapeutics targeting the Hedgehog pathway.