SGI 1027

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DNMT inhibitor

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Catalog No. A14120

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
SGI 1027 10mg A14120-10

Regular Price: $90.00

Special Price: $72.00

SGI 1027 25mg A14120-25

Regular Price: $180.00

Special Price: $144.00

SGI 1027 50mg A14120-50

Regular Price: $310.00

Special Price: $248.00

SGI 1027 10mM * 1mL in DMSO A14120-10mM-D

Regular Price: $110.00

Special Price: $88.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

SGI 1027 is a DNMT inhibitor with IC50 of 6, 8, 7.5 uM for DNMT1, DNMT3A, and DNMT3B, respectively.

SGI 1027

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Chemical Information

Catalog Num A14120
Actions Inhibitor
M. Wt 461.52
Formula C27H23N7O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1020149-73-8
Synonyms SGI-1027, SGI1027
SMILES code CC1=CC(=NC(=N1)N)NC2=CC=C(C=C2)NC(=O)C3=CC=C(C=C3)NC4=CC=NC5=CC=CC=C54
Chemical Name N-(4-((2-amino-6-methylpyrimidin-4-yl)amino)phenyl)-4-(quinolin-4-ylamino)benzamide

Biological Activity

Description
SGI 1027 is a DNMT inhibitor with IC50 of 6, 8, 7.5 uM for DNMT1, DNMT3A, and DNMT3B, respectively.
Targets
DNMT1 (Cell-free assay) DNMT3B (Cell-free assay) DNMT3A (Cell-free assay)
6 μM7.5 μM8 μM

Solubility

Solubility (25°C)* In vitro DMSO 92 mg/mL (199.34 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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