DNA Methyltransferases

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  1. Antioxidant, antiangiogenic, antitumor agent

    (-)-Epigallocatechin gallate is a potent anti-oxidant polyphenol flavonoid isolated from green tea.
  2. DNMT inhibitor

    Azacitidine is a chemical analogue of the cytosine nucleoside used in DNA and RNA that is mainly used in the treatment of myelodysplastic syndrome (MDS).
  3. DNA Methyltransferase Inhibitors

    Decitabine is a hypomethylating agent.It hypomethylates DNA by inhibiting DNA methyltransferase.
  4. MGMT inhibitor

    O6BTG-octylglucoside is a potent O6-methylguanine-DNAmethyl-transferase (MGMT) inhibitor, with IC50s of 32 nM in vitro (cell extracts) and 10 nM in HeLa S3 cells.
  5. DNA methyltransferase inhibitor

    Zebularine (NSC309132; 4-Deoxyuridine) is a DNA methyltransferase inhibitor.
  6. DNMT inhibitor

    SGI-110 is a second generation DNA-hypomethyating agent.
  7. MGMT inhibitor

    Lomeguatrib is a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase.
  8. DNA methyltransferase inhibitor

    RG108 is a non-nucleoside inhibitor of DNA methyltransferase with IC50 of 115 nM.
  9. DNMT inhibitor

    6-Methyl-5-azacytidine is a potent DNMT inhibitor.
  10. MGMT inhibitor

    O6-Benzylguanine is an effective substrate and efficient inactivator of DNA alkyltransferase. O6-Benzylguanine is an inhibitor of MGMT.
  11. DNMT inhibitor

    SGI 1027 is a DNMT inhibitor with IC50 of 6, 8, 7.5 uM for DNMT1, DNMT3A, and DNMT3B, respectively.
  12. Sodium channel blocker/DNMT inhibitor

    Procainamide HCl is a sodium channel blocker, and also a DNA methyltransferase inhibitor.
  13. G9a/DNMT inhibitor

    CM-272 is a reversible dual small molecule inhibitor against G9a and DNMTs in hematological malignancies. CAS: 1846570-31-7 (free base) 1846570-32-8 (TFA)
  14. G9a/DNMT inhibitor

    CM-579 is a first-in-class reversible, dual inhibitor of G9a and DNMT, with IC50 values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells.
  15. antineoplastic activity

    Guadecitabine, aslo known as SGI-110, is a dinucleotide antimetabolite of a decitabine linked via phosphodiester bond to a guanosine, with potential antineoplastic activity.
  16. Cytidine analog

    RX-3117(TV-1360; Fluorocyclopentenylcytosine) is novel a cytidine analog; shows anticancer activity in several cancer cell lines, including gemcitabine-resistant variants.
  17. β-Thujaplicin is a toxic tropolone derivative present in the heartwood of western red cedar (Thuja plicata) and is used as a preservative and antimicrobial additive in a number of commercial goods.
  18. DNMT1 inhibitor

    SW155246 is a potent and selective DNMT1 (DNA methyltransferase 1) inhibitor with IC50 of 1.2 μM. SW155246 induces re-expression of the tumor suppressor geneRASSF1 in A549 cells.

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