MKK/MEK inhibitor

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Catalog No. A14137

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
SL-327 10mg A14137-10

Regular Price: $40.00

Special Price: $34.00

SL-327 25mg A14137-25

Regular Price: $80.00

Special Price: $68.00

SL-327 50mg A14137-50

Regular Price: $240.00

Special Price: $204.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

SL-327 is a water soluble, structural homologue of the specific MKK1/2 inhibitor U0126 with IC50 of 0.18 uM and 0.22 uM for MEK1 and MEK2 respectively.


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Chemical Information

Catalog Num A14137
Actions Inhibitor
M. Wt 335.4
Formula C16H12F3N3S
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 305350-87-2
Synonyms SL 327, SL327
SMILES code C1=CC=C(C(=C1)C(=C(N)SC2=CC=C(C=C2)N)C#N)C(F)(F)F
Chemical Name ??-?[amino[(4-?aminophenyl)thio]methylene]-?2-?(trifluoromethyl)-?benzeneacetonitrile

Biological Activity

SL-327 is a water soluble, structural homologue of the specific MKK1/2 inhibitor U0126 with IC50 of 0.18 uM and 0.22 uM for MEK1 and MEK2 respectively.
Target Value
MEK1IC50: 0.18μM
MEK2IC50: 0.22μM
AP-1IC50: 2.03μM
PKCIC50: >10μM
MKK3/p38MAPKIC50: 21μM
ERK1IC50: >50μM
MKK4IC50: >100μM
JNKIC50: >100μM


Solubility (25°C)* In vitro DMSO 4 mg/mL (11.92 mM)
Water <1 mg/mL (<1 mM)
Ethanol 7 mg/mL (20.87 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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