Fig. 1 · Structure
Documents & Downloads
SR-3677 dihydrochloride
Cat. No.
A36840
CAS
1781628-88-3
Autophagy Inducer
SR-3677 dihydrochloride is a selective inhibitor of Rho-associated coiled-coil containing protein kinase I (ROCK-I) and II (ROCK-II), exhibiting IC50 values of 56 nM and 3 nM, respectively. This compound serves as an autophagy inducer, promoting cellular degradation pathways that can enhance cell survival and homeostasis. It is particularly useful in research focused on cancer, neurodegenerative diseases, and metabolic disorders, where modulation of autophagy may offer therapeutic benefits.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1781628-88-3 |
| Applications | Autophagy Inducer |
| Formula | C22H26Cl2N4O4 |
| Molecular Weight | 481.37 |
| SMILES | [H]Cl.[H]Cl.CN(C)CCOC1=C(NC(C2OC(C=CC=C3)=C3OC2)=O)C=CC(C4=CNN=C4)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.