TC-E 5001

TNKS inhibitor

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Catalog No. A11454

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
TC-E 5001 5mg A11454-5

Regular Price: $80.00

Special Price: $64.00

TC-E 5001 10mg A11454-10

Regular Price: $140.00

Special Price: $112.00

TC-E 5001 50mg A11454-50

Regular Price: $500.00

Special Price: $400.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

TC-E 5001 is dual tankyrase (TNKS) inhibitor (Kd values are 79 and 28 nM for TNKS1 and TNKS2 respectively, IC50 = 33 nM for TNKS2) that is devoid of activity at PARP1 and PARP2 (IC50 >19 uM). Inhibits Wnt signaling and stabilizes Axin2 levels.

TC-E 5001

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Chemical Information

Catalog Num A11454
Actions Inhibitor
M. Wt 409.46
Formula C20H19N5O3S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 865565-29-3
Synonyms TC-E5001, TC-E-5001
SMILES code CC(N1C(C=C2)=CC=C2OC)=NN=C1SCC3=NC(C(C=C4)=CC=C4OC)=NO3
Chemical Name 3-(4-methoxyphenyl)-5-(((4-(4-methoxyphenyl)-5-methyl-4H-1,2,4-triazol-3-yl)thio)methyl)-1,2,4-oxadiazole

Biological Activity

Description
TC-E 5001 is dual tankyrase (TNKS) inhibitor (Kd values are 79 and 28 nM for TNKS1 and TNKS2 respectively, IC50 = 33 nM for TNKS2) that is devoid of activity at PARP1 and PARP2 (IC50 >19 uM). Inhibits Wnt signaling and stabilizes Axin2 levels.

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