TGX-221

PI3K Inhibitor

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Catalog No. A10923

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
TGX-221 5mg A10923-5
$45.00
TGX-221 10mg A10923-10
$75.00
TGX-221 25mg A10923-25
$150.00
TGX-221 100mg A10923-100
$250.00
TGX-221 10mM * 1mL in DMSO A10923-10mM-D
$92.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

TGX-221 is a potent, selective, and cell permeable inhibitor of PI3K p110β.

TGX-221

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Chemical Information

Catalog Num A10923
Actions Inhibitor
M. Wt 364.4
Formula C21H24N4O2
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 663619-89-4
Synonyms TGX221
SMILES code CC1=CN2C(=O)C=C(N=C2C(=C1)C(C)NC3=CC=CC=C3)N4CCOCC4
Chemical Name 7-​methyl-​2-​(4-​morpholinyl)-​9-​[1-​(phenylamino)ethyl]-​4H-​pyrido[1,​2-​a]pyrimidin-​4-​one

Biological Activity

Description
TGX-221 is a potent, selective, and cell permeable inhibitor of PI3K p110β.
Targets
Target Value
p110βIC50: 5nM
p110δIC50: 0.1μM
p110αIC50: 5μM
p110γIC50: >10μM
C2αIC50: >10μM
PI4KIC50: >10μM
AblIC50: >10μM
EGFRIC50: >10μM
FynIC50: >10μM
HER2IC50: >10μM
Insulin ReceptorIC50: >10μM
CaseinKinase2IC50: >10μM
CDK2/CyclinAIC50: >10μM
ERK1IC50: >10μM
p38αIC50: >10μM
p70S6KIC50: >10μM
PKAIC50: >10μM
PKCIC50: >10μM
CaMKIC50: >10μM

Solubility

Solubility (25°C) * In vitro DMSO 12 mg/mL (32.92 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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