Tipifarnib (Zarnestra)

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FTase inhibitor

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Catalog No. A10935

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Tipifarnib 5mg A10935-5

Regular Price: $150.00

Special Price: $127.50

Tipifarnib 10mg A10935-10

Regular Price: $250.00

Special Price: $212.50

Tipifarnib 25mg A10935-25

Regular Price: $450.00

Special Price: $382.50

Tipifarnib 100mg A10935-100

Regular Price: $800.00

Special Price: $680.00

Tipifarnib (Zarnestra) 10mM * 1mL in DMSO A10935-10mM-D

Regular Price: $206.00

Special Price: $175.10

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Tipifarnib (Zarnestra) is a farnesyltransferase inhibitor that inhibits the Ras kinase in a post translational modification step before the kinase pathway becomes hyperactive.

Tipifarnib (Zarnestra)

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Chemical Information

Catalog Num A10935
Actions Inhibitor
M. Wt 489.4
Formula C27H22Cl2N4O
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 192185-72-1
Synonyms IND 58359, R115777
SMILES code CN1C=NC=C1[C@@](C2=CC=C(C=C2)Cl)(C3=CC4=C(C=C3)N(C(=O)C=C4C5=CC(=CC=C5)Cl)C)N
Chemical Name 6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2(1H)-one

Biological Activity

Description
Tipifarnib (Zarnestra) is a farnesyltransferase inhibitor that inhibits the Ras kinase in a post translational modification step before the kinase pathway becomes hyperactive.
Targets
FTase
0.6 nM

Solubility

Solubility (25°C) * In vitro DMSO 14 mg/mL (28.6 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 15% Captisol/citrate vehicle 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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A11002 YM155 89 mg/mL 55 mg/mL 6 mg/mL
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