URMC-099

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Catalog No. A14219

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
URMC-099 5mg A14219-5

Regular Price: $70.00

Special Price: $59.50

URMC-099 10mg A14219-10

Regular Price: $120.00

Special Price: $102.00

URMC-099 25mg A14219-25

Regular Price: $220.00

Special Price: $187.00

URMC-099 10mM * 1mL in DMSO A14219-10mM-D

Regular Price: $88.00

Special Price: $74.80

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

URMC-099 is an orally bioavailable, brain penetrant mixed lineage kinase (MLK) inhibitor with IC50 of 19 nM, 42 nM, 14 nM, and 150 nM, for MLK1, MLK2, MLK3, and DLK, respectively.

URMC-099

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Chemical Information

Catalog Num A14219
Actions No
M. Wt 421.54
Formula C27H27N5
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1229582-33-5
Synonyms URMC 099,URMC099
SMILES code CN1CCN(CC1)CC2=CC=C(C=C2)C3=CN=C4C(=C3)C(=CN4)C5=CC6=C(C=C5)NC=C6
Chemical Name 3-(1H-indol-5-yl)-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridine

Biological Activity

Description
URMC-099 is an orally bioavailable, brain penetrant mixed lineage kinase (MLK) inhibitor with IC50 of 19 nM, 42 nM, 14 nM, and 150 nM, for MLK1, MLK2, MLK3, and DLK, respectively.
Targets
Target Value
Abl1IC50: 6.5nM
LRRK2IC50: 11nM
MLK3IC50: 14nM
MLK1IC50: 19nM
VEGFR1/FLT1IC50: 39nM
MLK2IC50: 42nM
SGKIC50: 67nM
TrkAIC50: 85nM
AuroraAIC50: 108nM
ROCK2IC50: 111nM
AuroraBIC50: 123nM
DLKIC50: 150nM
c-MetIC50: 177nM
IRIC50: 200nM
SGK1IC50: 201nM
TrkBIC50: 217nM
AuroraCIC50: 290nM
IGF-1RIC50: 307nM
LCKIC50: 333nM
MEKK2IC50: 661nM
SykIC50: 731nM
ROCK1IC50: 1030nM
CDK1IC50: 1125nM
CDK2IC50: 1180nM
AMPKIC50: 1512nM
JNK1IC50: 3280nM
SrcIC50: 4330nM
ZAP70IC50: 5050nM
ERK2IC50: 6290nM
GSK-3βIC50: >10000nM
p38αIC50: 12050nM

Solubility

Solubility (25°C)* In vitro DMSO 84 mg/mL (199.26 mM)
Water <1 mg/mL (<1 mM)
Ethanol 84 mg/mL (199.26 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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