Vandetanib (ZD6474)

Vandetanib (Zactima) is a VEGFR and EGFR antagonist and a tyrosine kinase inhibitor with IC50 of 60, 90, 40 nM for HUVEC proliferation, PC-9 cells and tyrosine kinase activity, respectively.
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Product Name Price Stock Qty
Vandetanib 25mg
$60.00
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Vandetanib 50mg
$100.00
In stock
Vandetanib 100mg
$200.00
In stock
Vandetanib 500mg
$450.00
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Adooq Products cited in reputable paper
Adooq's Vandetanib (ZD6474) has been cited by 10 publications
  • Ayaka Kojima, .et al. , Xenobiotica, 2022, Jul;52(7):669-675 PMID: 36251932
  • Aya Hasan Alshammari, .et al. , Biochem Pharmacol, 2022, Mar;197:114914 PMID: 35041812
  • Majid Momeny, .et al. , Life Sci, 2021, Dec 15;287:120100 PMID: 34715143
  • Shinya Kitamura, .et al. , Biochem Biophys Res Commun, 2020, Aug 13 PMID: 32800552
  • Majid Momeny, .et al. , Eur J Pharmacol, 2020, 882:173298
  • Rintaro Sogawa, .et al. , JPA, 2018, in Press PMID: 30740257
  • Park K, .et al. , Anat Sci Int, 2018, Jun;93(3):372-383 PMID: 29256114
  • Brittany M. Duggan, .et al. , Sci Rep, 2017, 7: 1578 PMID: 28484277
  • Fujita KI, .et al. , J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358
  • Park K, .et al. , Biomed Pharmacother, 2016, Mar;78:140-149 PMID: 26898435
  • Biological Activity
    Discription Vandetanib (Zactima) is a VEGFR and EGFR antagonist and a tyrosine kinase inhibitor with IC50 of 60, 90, 40 nM for HUVEC proliferation, PC-9 cells and tyrosine kinase activity, respectively.
    Targets
    Target Value
    Product Information
    Catalog Num A10963
    Formula C22H24BrFN4O2
    Molecular Weight 475.4
    CAS Number 443913-73-3
    SMILES CN1CCC(CC1)COC2=C(C=C3C(=C2)N=CN=C3NC4=C(C=C(C=C4)Br)F)OC
    Synonyms ZD6474
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 4 mg/mL (8.41 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 1% CMC Na 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 21.03 mL 105.17 mL 210.35 mL
    0.5 mM 4.21 mL 21.03 mL 42.07 mL
    1 mM 2.1 mL 10.52 mL 21.03 mL
    5 mM 0.42 mL 2.1 mL 4.21 mL
    Useful Calculator

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    This equation is commonly abbreviated as: C1V1 = C2V2

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