VX-702

Catalog No.: A10982
p38 MAPK inhibitor
VX-702 is an orally bioavailable inhibitor of p38 MAP kinase that inhibits platelet agonist induced p38 activation (IC50= 4 to 20 nM).
Grouped product items
Product Name Price Stock Qty
VX-702 10mg
$40.00
In stock
VX-702 50mg
$100.00
In stock
VX-702 100mg
$190.00
In stock
VX-702 200mg
$320.00
In stock
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Biological Activity
Discription VX-702 is an orally bioavailable inhibitor of p38 MAP kinase that inhibits platelet agonist induced p38 activation (IC50= 4 to 20 nM).
Product Information
Catalog Num A10982
Formula C19H12F4N4O2
Molecular Weight 404.3
CAS Number 479543-46-9, 745833-23-2
SMILES C1=CC(=C(C(=C1)F)N(C2=NC(=C(C=C2)C(=O)N)C3=C(C=C(C=C3)F)F)C(=O)N)F
Synonyms VX702, VX 702
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO 77 mg/mL (190.45 mM)
Water Insoluble
Ethanol Insoluble
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.73 mL 123.67 mL 247.34 mL
0.5 mM 4.95 mL 24.73 mL 49.47 mL
1 mM 2.47 mL 12.37 mL 24.73 mL
5 mM 0.49 mL 2.47 mL 4.95 mL
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