VX-745

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p38 MAPK inhibitor

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Catalog No. A10983

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
VX-745 5mg A10983-5

Regular Price: $60.00

Special Price: $48.00

VX-745 10mg A10983-10

Regular Price: $90.00

Special Price: $72.00

VX-745 50mg A10983-50

Regular Price: $360.00

Special Price: $288.00

VX-745 100mg A10983-100

Regular Price: $600.00

Special Price: $480.00

VX-745 10mM * 1mL in DMSO A10983-10mM-D

Regular Price: $120.00

Special Price: $96.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

VX-745 is a small-molecule inhibitor of MAPK that is reported to be active against several isotypes of p38 MAPK, including p38α, p38βand p38γ .

VX-745

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Chemical Information

Catalog Num A10983
Actions Inhibitor
M. Wt 436.3
Formula C19H9Cl2F2N3OS
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 209410-46-8
Synonyms VX745
SMILES code C1=CC(=C(C(=C1)Cl)C2=C3C=CC(=NN3C=NC2=O)SC4=C(C=C(C=C4)F)F)Cl
Chemical Name 5-(2,6-Dichlorophenyl)-2-[2,4-difluorophenyl)thio]-6H-pyrimido[1,6-b]pyridazin-6-one

Biological Activity

Description
VX-745 is a small-molecule inhibitor of MAPK that is reported to be active against several isotypes of p38 MAPK, including p38α, p38βand p38γ .
Targets
p38α p38β
10 nM220 nM

Solubility

Solubility (25°C) * In vitro DMSO 15 mg/mL (34.38 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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