VX-765 (Belnacasan)

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Caspase-1/4 inhibitor

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Catalog No. A10984

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
VX-765 5mg A10984-5

Regular Price: $70.00

Special Price: $59.50

VX-765 10mg A10984-10

Regular Price: $98.00

Special Price: $83.30

VX-765 50mg A10984-50

Regular Price: $250.00

Special Price: $212.50

VX-765 100mg A10984-100

Regular Price: $450.00

Special Price: $382.50

VX-765 10mM * 1mL in DMSO A10984-10mM-D

Regular Price: $75.00

Special Price: $63.75

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

VX-765 is a novel Caspase-1 inhibitor,which is an enzyme that controls the generation of two cytokines, IL-1b and IL-18.

VX-765 (Belnacasan)

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Chemical Information

Catalog Num A10984
Actions Inhibitor
M. Wt 509.0
Formula C24H33ClN4O6
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 273404-37-8
Synonyms VX765
SMILES code CCO[[email protected]]1[[email protected]](CC(=O)O1)NC(=O)[C@@H]2CCCN2C(=O)[[email protected]](C(C)(C)C)NC(=O)C3=CC(=C(C=C3)N)Cl
Chemical Name (S)-1-((S)-2-{[1-(4-amino-3-chloro-phenyl)-methanoyl]-amino}-3,3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2R,3S)-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide

Biological Activity

Description
VX-765 is a novel Caspase-1 inhibitor,which is an enzyme that controls the generation of two cytokines, IL-1b and IL-18.
Targets
Caspase-4 (Cell-free assay) Caspase-1 (Cell-free assay)
<0.6 nM(Ki)0.8 nM(Ki)

Solubility

Solubility (25°C)* In vitro DMSO 100 mg/mL heating (196.46 mM)
Water <1 mg/mL (<1 mM)
Ethanol 100 mg/mL heating (196.46 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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