WHI-P 154 is a JAK3 inhibitor with IC50 = 1.8uM. WHI-P 154 also Inhibits STAT1 activation, iNOS expression and NO production in macrophages in vitro.
Targets
Target
Value
Cell Research
Cell Line
Type
Value
Description
References
Product Information
Catalog Num
A14049
Formula
C16H14BrN3O3
Molecular Weight
376.2
CAS Number
211555-04-3
SMILES
COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)O)Br)OC
Synonyms
WHI-P154
Storage
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
Solubility
In vitro (25°C)
DMSO
74 mg/mL (196.7 mM)
Water
Insoluble
Ethanol
Insoluble
In vivo
30% propylene glycol, 5% Tween 80, 65% D5W
28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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