JAK Inhibitor

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Catalog No. A11795

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
WP1066 10mg A11795-10

Regular Price: $60.00

Special Price: $54.00

WP1066 25mg A11795-25

Regular Price: $140.00

Special Price: $126.00

WP1066 50mg A11795-50

Regular Price: $210.00

Special Price: $189.00

WP1066 10mM * 1mL in DMSO A11795-10mM-D

Regular Price: $70.00

Special Price: $63.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

WP1066 is a novel JAK2 inhibitor and it suppresses proliferation and induces apoptosis in eythroid human cells carrying the JAK2 V617F mutation.


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Chemical Information

Catalog Num A11795
Actions Inhibitor
M. Wt 356.2
Formula C17H14BrN3O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 857064-38-1
Synonyms WP 1066, WP-1066
SMILES code C[[email protected]@H](C1=CC=CC=C1)NC(=O)/C(=C/C2=NC(=CC=C2)Br)/C#N
Chemical Name (E)-3(6-bromopyridin-2-yl)-2-cyano-N-(S0-1phenylethyl)acrylamide

Biological Activity

WP1066 is a novel JAK2 inhibitor and it suppresses proliferation and induces apoptosis in eythroid human cells carrying the JAK2 V617F mutation.
JAK2 (HEL cells) STAT3 (HEL cells)
2.3 μM2.43 μM


Solubility (25°C)* In vitro DMSO 71 mg/mL (199.31 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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