WP1130 (Degrasyn)

Catalog No.: A10988
DUB/Bcr/ABL Inhibitor
WP1130 (Degrasyn) is a novel selective small molecular deubiquitinase inhibitor and a Bcr/Abl destruction pathway activator that specifically and rapidly down-regulates both wild-type and mutant Bcr/Abl protein without affecting bcr/abl gene expression in chronic myelogenous leukemia (CML) cells.
Grouped product items
Product Name Price Stock Qty
WP1130 5mg
$60.00
In stock
WP1130 10mg
$100.00
In stock
WP1130 50mg
$280.00
In stock
WP1130 100mg
$450.00
In stock
WP1130 10mM * 1mL in DMSO
$105.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's WP1130 (Degrasyn) has been cited by 1 publications
  • Kevin Bohm, .et al. , Arch Pharm (Weinheim), 2023, Jul;356(7):e2200661 PMID: 37196427
  • Biological Activity
    Discription WP1130 (Degrasyn) is a novel selective small molecular deubiquitinase inhibitor and a Bcr/Abl destruction pathway activator that specifically and rapidly down-regulates both wild-type and mutant Bcr/Abl protein without affecting bcr/abl gene expression in chronic myelogenous leukemia (CML) cells.
    Targets
    Target Value
    Product Information
    Catalog Num A10988
    Formula C19H18BrN3O
    Molecular Weight 384.3
    CAS Number 856243-80-6
    SMILES CCC[C@@H](C1=CC=CC=C1)NC(=O)/C(=C/C2=NC(=CC=C2)Br)/C#N
    Synonyms WP-1130, Degrasyn
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro DMSO 73 mg/mL (189.96 mM)
    Water Insoluble
    Ethanol 17 mg/mL (44.24 mM)
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 26.02 mL 130.11 mL 260.21 mL
    0.5 mM 5.2 mL 26.02 mL 52.04 mL
    1 mM 2.6 mL 13.01 mL 26.02 mL
    5 mM 0.52 mL 2.6 mL 5.2 mL
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