WP1130 ( Degrasyn )

DUB/Bcr/ABL Inhibitor

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Catalog No. A10988

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
WP1130 5mg A10988-5
$60.00
WP1130 10mg A10988-10
$100.00
WP1130 50mg A10988-50
$280.00
WP1130 100mg A10988-100
$450.00
WP1130 10mM * 1mL in DMSO A10988-10mM-D
$105.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

WP1130 (Degrasyn) is a novel selective small molecular deubiquitinase inhibitor and a Bcr/Abl destruction pathway activator that specifically and rapidly down-regulates both wild-type and mutant Bcr/Abl protein without affecting bcr/abl gene expression in chronic myelogenous leukemia (CML) cells.

WP1130 ( Degrasyn )

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Chemical Information

Catalog Num A10988
Actions Inhibitor
M. Wt 384.3
Formula C19H18BrN3O
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 856243-80-6
Synonyms WP-1130, Degrasyn
SMILES code CCC[[email protected]@H](C1=CC=CC=C1)NC(=O)/C(=C/C2=NC(=CC=C2)Br)/C#N
Chemical Name (2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylbutyl]-2-propenamide

Biological Activity

Description
WP1130 (Degrasyn) is a novel selective small molecular deubiquitinase inhibitor and a Bcr/Abl destruction pathway activator that specifically and rapidly down-regulates both wild-type and mutant Bcr/Abl protein without affecting bcr/abl gene expression in chronic myelogenous leukemia (CML) cells.
Targets
DUB (Cell-free assay) Bcr-Abl (Cell-free assay)
N/A1.8 μM

Solubility

Solubility (25°C)* In vitro DMSO 77 mg/mL (200.37 mM)
Water <1 mg/mL (<1 mM)
Ethanol 18 mg/mL (46.84 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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