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mTOR Inhibitor

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Catalog No. A10989

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
WYE-354 5mg A10989-5

Regular Price: $60.00

Special Price: $54.00

WYE-354 10mg A10989-10

Regular Price: $100.00

Special Price: $90.00

WYE-354 25mg A10989-25

Regular Price: $220.00

Special Price: $198.00

WYE-354 50mg A10989-50

Regular Price: $400.00

Special Price: $360.00

WYE-354 10mM * 1mL in DMSO A10989-10mM-D

Regular Price: $118.00

Special Price: $106.20

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

WYE-354 is a potent cell-permeable inhibitor of mTOR (IC50 = 4.3 nM) which blocks signaling through both mTOR complex 1 (mTORC1) and mTORC2. It is a much weaker inhibitor of PI3K α (IC50 = 1026 nM) and other kinases.


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Chemical Information

Catalog Num A10989
Actions Inhibitor
M. Wt 495.5
Formula C24H29N7O5
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1062169-56-5
Synonyms WYE354
Chemical Name 4-​[6-​[4-​[(methoxycarbonyl)amino]phenyl]-​4-​(4-​morpholinyl)-​1H-​pyrazolo[3,​4-​d]pyrimidin-​1-​yl]-​methyl ester-​1-​piperidinecarboxylic acid

Biological Activity

WYE-354 is a potent cell-permeable inhibitor of mTOR (IC50 = 4.3 nM) which blocks signaling through both mTOR complex 1 (mTORC1) and mTORC2. It is a much weaker inhibitor of PI3K α (IC50 = 1026 nM) and other kinases.
Target Value
mTORIC50: 5nM
PI3KαIC50: 1.89μM
PI3KγIC50: 7.37μM
GCKIC50: >50μM
HckIC50: >50μM
IKKαIC50: >50μM
LynIC50: >50μM
MetIC50: >50μM
MK2IC50: >50μM
p38αIC50: >50μM
PDGFRαIC50: >50μM
PKAIC50: >50μM
PKBαIC50: >50μM
PKCαIC50: >50μM
PKCβIC50: >50μM
ROCK1IC50: >50μM
RSK1IC50: >50μM
SrcIC50: >50μM
VEGFR2IC50: >50μM
Abl1IC50: >50μM
AuroraBIC50: >50μM
CDK1/CyclinBIC50: >50μM
CDK2/CyclinAIC50: >50μM
Chk1IC50: >50μM
ERK2IC50: >50μM
FynIC50: >50μM


Solubility (25°C) * In vitro DMSO 99 mg/mL (199.78 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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