XEN445

Catalog No.: A13150
Endothelial lipase(EL) inhibitor
XEN445 is a potent and selective EL inhibitor(IC50=0.237 uM), that showed good ADME and PK properties, and demonstrated in vivo efficacy in raising plasma HDLc concentrations in mice.
Grouped product items
Product Name Price Stock Qty
XEN445 2mg
$40.00
In stock
XEN445 5mg
$65.00
In stock
XEN445 10mg
$120.00
In stock
XEN445 10mM * 1mL in DMSO
$110.00
In stock
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Biological Activity
Discription XEN445 is a potent and selective EL inhibitor(IC50=0.237 uM), that showed good ADME and PK properties, and demonstrated in vivo efficacy in raising plasma HDLc concentrations in mice.
Targets
Target Value
Product Information
Catalog Num A13150
Formula C18H17F3N2O3
Molecular Weight 366.33
CAS Number 1515856-92-4
SMILES C1CN(CC1OCC2=CC=CC=N2)C3=C(C=C(C=C3)C(F)(F)F)C(=O)O
Synonyms XEN-445, XEN 445
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro DMSO 79 mg/mL (215.65 mM)
Water Insoluble
Ethanol Warmed: 34 mg/mL (92.81 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.3 mL 136.49 mL 272.98 mL
0.5 mM 5.46 mL 27.3 mL 54.6 mL
1 mM 2.73 mL 13.65 mL 27.3 mL
5 mM 0.55 mL 2.73 mL 5.46 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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