Catalog No.
Product Name
Application
Product Information
Product Citation
- Clofibrate increases the activity of extrahepatic lipoprotein lipase (LL), thereby increasing lipoprotein triglyceride lipolysis. Chylomicrons are degraded, VLDLs are converted to LDLs, and LDLs are converted to HDL.
- Tanshinone IIA (TIIA) is one of the major extracts obtained from Salvia miltiorrhiza BUNGE, which has anti-inflammatory and anti-apoptotic effects on many diseases.
- Qiwen Yan, .et al. , Regen Ther, 2023, Dec; 24: 417-425 PMID: 37727797
- Judith Schaf, .et al. , Cell Death Discov, 2023, May 19;9(1):172 PMID: 37202382
- Williams R, .et al. , Research Square, 2022, NOV 21
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dual FAAH/MAGL inhibitor
JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor with IC50 of 13 nM and 19 nM for mouse brain FAAH and MAGL respectively.- Lakhan S Khara, .et al. , J Exp Biol, 2022, May 1;225(9):jeb244146 PMID: 35438163
- Md Shah Sufian, .et al. , J Exp Biol, 2021, 21 JUNE
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MAGL Inhibitor
JZL184 is a potent and selective monoacylglycerol lipase (MAGL) inhibitor. Blocks hydrolysis of the endocannabinoid 2-arachidonyl glycerol (2-AG) in vivo in the mouse brain (IC50 = 8 nM).- Lakhan S Khara, .et al. , J Exp Biol, 2022, May 1;225(9):jeb244146 PMID: 35438163
- Md Shah Sufian, .et al. , J Exp Biol, 2021, 21 JUNE
- Toshihiko Tsutsumi, .et al. , Biochim Biophys Acta Mol Cell Biol Lipids, 2020, Sep;1865(9):158761 PMID: 32629025
- Rea Pihlaja, .et al. , Front Neurosci, 2017, 11: 299 PMID: 28611577
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ATGL inhibitor
Atglistatin is a highly potent, selective and competitive inhibitor of adipose triglyceride lipase (ATGL) with an IC50 of ~0.7 μM for inhibition of lipolysis in vitro, but no toxicity up to a concentration of 50 μM. - Dihydroberberine is an inhibitor of pancreatic lipase with IC50 value of 8 mg/ml.
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lipase inhibitor
Cetilistat is a drug designed to treat obesity. It acts in the same way as the older drug orlistat (Xenical) by inhibiting pancreatic lipase, an enzyme that breaks down triglycerides in the intestine. -
covalent MAGL inhibitor
PF-06795071 is a potent and selective covalent MAGL inhibitor with an IC50 of 3 nM. -
endothelial lipase inhibitor
Endothelial lipase inhibitor-1 is a potent endothelial lipase inhibitor with an IC50 of 49 nM.
