XL019

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JAK2 inhibitor

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Catalog No. A12394

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
XL019 5mg A12394-5

Regular Price: $90.00

Special Price: $72.00

XL019 10mg A12394-10

Regular Price: $150.00

Special Price: $120.00

XL019 25mg A12394-25

Regular Price: $250.00

Special Price: $200.00

XL019 100mg A12394-100

Regular Price: $750.00

Special Price: $600.00

XL019 10mM * 1mL in DMSO A12394-10mM-D

Regular Price: $139.00

Special Price: $111.20

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

XL019 is an orally bioavailable inhibitor of Janus-associated kinase 2 (JAK2) with potential antineoplastic activity.

XL019

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Chemical Information

Catalog Num A12394
Actions Inhibitor
M. Wt 444.53
Formula C25H28N6O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 945755-56-6
Synonyms XL 019, XL-019
SMILES code C1C[[email protected]](NC1)C(=O)NC2=CC=C(C=C2)C3=NC(=NC=C3)NC4=CC=C(C=C4)N5CCOCC5
Chemical Name (S)-N-(4-(2-((4-morpholinophenyl)amino)pyrimidin-4-yl)phenyl)pyrrolidine-2-carboxamide

Biological Activity

Description
XL019 is an orally bioavailable inhibitor of Janus-associated kinase 2 (JAK2) with potential antineoplastic activity.
Targets
Target Value
JAK2IC50: 2.2nM
PDGFRβIC50: 125.4nM
JAK1IC50: 134.3nM
FLT3IC50: 139.7nM
JAK3IC50: 214.2nM
c-KitIC50: 225.8nM
p70S6KIC50: 313.8nM
TYK2IC50: 348.3nM
MLK1IC50: 370.0nM
IKKβIC50: 375.4nM
KDRIC50: 483.6nM
PDGFRαIC50: 546.7nM
FLT4IC50: 554.5nM
FLT1IC50: 910.5nM

Solubility

Solubility (25°C)* In vitro DMSO 16 mg/mL (35.99 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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