XL147

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PI3K Inhibitor

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Catalog No. A10995

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
XL147 10mg A10995-10

Regular Price: $100.00

Special Price: $85.00

XL147 25mg A10995-25

Regular Price: $200.00

Special Price: $170.00

XL147 50mg A10995-50

Regular Price: $280.00

Special Price: $238.00

XL147 100mg A10995-100

Regular Price: $480.00

Special Price: $408.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

XL147 is a potent, selective and orally bioavailable small molecule inhibitor of class I phosphatidylinositol 3 kinase (PI3K) with potential antineoplastic activity.

XL147

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Chemical Information

Catalog Num A10995
Actions Inhibitor
M. Wt 448.5
Formula C21H16N6O2S2
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 956958-53-5
Synonyms XL-147, SAR245408
SMILES code CC1=CC=C(C=C1)S(=O)(=O)NC2=NC3=CC=CC=C3N=C2NC4=CC5=NSN=C5C=C4
Chemical Name N-[3-(2,1,3-Benzothiadiazol-5-ylamino)-2-quinoxalinyl]-4-methylbenzenesulfonamide

Biological Activity

Description
XL147 is a potent, selective and orally bioavailable small molecule inhibitor of class I phosphatidylinositol 3 kinase (PI3K) with potential antineoplastic activity.
Targets
Target Value
PI3KγIC50: 23nM
PI3KδIC50: 36nM
PI3KαIC50: 39nM
PI3KβIC50: 383nM
DNA-PKIC50: 4.75μM
Vps34IC50: 6.975μM
MEKIC50: >10μM
B-Raf/C-RafIC50: >10μM
mTORIC50: >15μM

Solubility

Solubility (25°C) * In vitro DMSO 3 mg/mL (6.68 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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