XL765 ON SALE PI3K inhibitor

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Catalog No. A10997

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
XL765 5mg A10997-5

Regular Price: $90.00

Special Price: $76.50

XL765 10mg A10997-10

Regular Price: $160.00

Special Price: $136.00

XL765 50mg A10997-50

Regular Price: $450.00

Special Price: $382.50

XL765 100mg A10997-100

Regular Price: $750.00

Special Price: $637.50

XL765 10mM * 1mL in DMSO A10997-10mM-D

Regular Price: $167.00

Special Price: $141.95

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

XL765 is a PI3K/mTOR dual kinase inhibitor and it is more potent compared to an agent that inhibits either PI3K kinase or mTOR kinase alone.

XL765

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Chemical Information

Catalog Num A10997
Actions Inhibitor
M. Wt 599.7
Formula C31H29N5O6S
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1349796-36-6
Synonyms XL-765
SMILES code CC1=C(C=C(C=C1)C(=O)NC2=CC=C(C=C2)S(=O)(=O)NC3=NC4=CC=CC=C4N=C3NC5=CC(=CC(=C5)OC)OC)OC
Chemical Name N-[2-[(3,5-Dimethoxyphenyl)amino]quinoxalin-3-yl]-4-[(4-methyl-3-methoxyphenyl)carbonyl]aminophenylsulfonamide

Biological Activity

Description
XL765 is a PI3K/mTOR dual kinase inhibitor and it is more potent compared to an agent that inhibits either PI3K kinase or mTOR kinase alone.
Targets
Target Value
PI3KγIC50: 9nM
PI3KαIC50: 39nM
PI3KδIC50: 43nM
PI3KβIC50: 113nM
DNA-PKIC50: 150nM
mTORIC50: 157nM

Solubility

Solubility (25°C) * In vitro DMSO 12 mg/mL (20.01 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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