Aurora Kinase inhibitor

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Catalog No. A11009

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
ZM-447439 5mg A11009-5

Regular Price: $40.00

Special Price: $34.00

ZM-447439 10mg A11009-10

Regular Price: $70.00

Special Price: $59.50

ZM-447439 25mg A11009-25

Regular Price: $150.00

Special Price: $127.50

ZM-447439 50mg A11009-50

Regular Price: $260.00

Special Price: $221.00

ZM-447439 10mM * 1mL in DMSO A11009-10mM-D

Regular Price: $100.00

Special Price: $85.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

ZM-447439 is a potein, selective ATP-competitive Aurora B kinase inhibitor with an IC50 of 50 nM, 1 μM and 250 nM for Aurora B, A and C, respectively.


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Chemical Information

Catalog Num A11009
Actions Inhibitor
M. Wt 513.6
Formula C29H31N5O4
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 331771-20-1
Synonyms ZM447439
Chemical Name N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamide

Biological Activity

ZM-447439 is a potein, selective ATP-competitive Aurora B kinase inhibitor with an IC50 of 50 nM, 1 μM and 250 nM for Aurora B, A and C, respectively.
Target Value
AuroraAIC50: 110nM
AuroraBIC50: 130nM
LCKIC50: 880nM
SrcIC50: 1.03μM
MEK1IC50: 1.79μM
CDK1IC50: >10μM
CDK2IC50: >10μM
CDK4IC50: >10μM
PLK1IC50: >10μM
Chk1IC50: >10μM
IKK1IC50: >10μM
IKK2IC50: >10μM
cFLT2IC50: >10μM
KDR2IC50: >10μM
ZAP70IC50: >10μM
FAKIC50: >10μM


Solubility (25°C) * In vitro DMSO 103 mg/mL (200.54 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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