10-Nitrocamptothecin

Name: 10-Nitrocamptothecin
Brand: Adooq Bioscience
SKU: A57139
Rating: 5 (288 reviews)

Catalog No.: A57139

Topoisomerase I Inhibitor

10-Nitrocamptothecin is a potent inhibitor of topoisomerase I, exhibiting an IC50 value of 0.64 μM. This compound disrupts the formation of cleavable complexes, thereby effectively inhibiting topoisomerase I activity. It is widely utilized in cancer research to explore therapeutic strategies targeting DNA replication and repair mechanisms.

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10-Nitrocamptothecin 86639-62-5 Topoisomerase I Inhibitor

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Biological Activity

Description	10-Nitrocamptothecin is a potent inhibitor of topoisomerase I, exhibiting an IC50 value of 0.64 μM. This compound disrupts the formation of cleavable complexes, thereby effectively inhibiting topoisomerase I activity. It is widely utilized in cancer research to explore therapeutic strategies targeting DNA replication and repair mechanisms.

Product Information

Catalog Num	A57139
Formula	C20H15N3O6
Molecular Weight	393.35
CAS Number	86639-62-5
SMILES	O=C1N2C(C(C(C2)=CC3=C4)=NC3=CC=C4[N+]([O-])=O)=CC5=C1COC([C@]5(O)CC)=O

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