103D5R is a potent inhibitor of hypoxia-inducible factor-1 (HIF-1) activation, exhibiting an IC50 of 35 µM through the suppression of HIF-1α protein synthesis. This compound also inhibits the proliferation of LN229 cells, with an IC50 of 26 µM, making it a valuable tool for research into tumor biology and the molecular mechanisms of hypoxia. Its applications extend to studies exploring the role of HIF-1 in cancer progression and therapy resistance.
103D5R is a potent inhibitor of hypoxia-inducible factor-1 (HIF-1) activation, exhibiting an IC50 of 35 µM through the suppression of HIF-1α protein synthesis. This compound also inhibits the proliferation of LN229 cells, with an IC50 of 26 µM, making it a valuable tool for research into tumor biology and the molecular mechanisms of hypoxia. Its applications extend to studies exploring the role of HIF-1 in cancer progression and therapy resistance.
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