15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is an endogenous cyclopentenone prostaglandin that targets peroxisome proliferator-activated receptors, specifically acting as a selective agonist for PPARγ with an EC50 of 2 µM and a covalent agonist for PPARδ. This compound is known to facilitate the differentiation of C3H10T1/2 fibroblasts into adipocytes with an EC50 of 7 μM. Due to its effects on adipogenesis and metabolism, 15d-PGJ2 is utilized in research exploring obesity, diabetes, and metabolic syndrome pathways.
15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is an endogenous cyclopentenone prostaglandin that targets peroxisome proliferator-activated receptors, specifically acting as a selective agonist for PPARγ with an EC50 of 2 µM and a covalent agonist for PPARδ. This compound is known to facilitate the differentiation of C3H10T1/2 fibroblasts into adipocytes with an EC50 of 7 μM. Due to its effects on adipogenesis and metabolism, 15d-PGJ2 is utilized in research exploring obesity, diabetes, and metabolic syndrome pathways.
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