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|Storage||at -20°C 3 years Powder|
|Synonyms||17DMAG, NSC 707545|
|Chemical Name||17-Demethoxy-17-[[2-(dimethylamino) ethyl]amino]geldanamycin hydrochloride|
|17-DMAG is a water-soluble analog of 17-AAG and geldanamycin that binds the ATP binding site of Hsp90 and inhibits its chaperone activity. Displays more potent antitumor activity than 17-AAG.|
|Solubility (25°C) *||In vitro||DMSO||131 mg/mL (200.54 mM)|
|Water||<1 mg/mL (<1 mM)|
|Ethanol||<1 mg/mL (<1 mM)|
|In vivo||1% DMSO/30% polyethylene glycol/1% Tween 80||30 mg/mL|
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||15.31 mL||76.55 mL||153.09mL|
|0.5 mM||3.06 mL||15.31 mL||30.62 mL|
|1 mM||1.53 mL||7.65 mL||15.31 mL|
|5 mM||0.31 mL||1.53 mL||3.06 mL|
*The above data is based on the productmolecular weight 653.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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