(1S,2S)-Bortezomib is a selective proteasome inhibitor with a high affinity for the 20S proteasome, exhibiting a Ki of 0.6 nM. This compound disrupts the cell cycle and induces apoptosis by targeting a threonine residue, ultimately leading to the inhibition of NF-κB signaling. As an enantiomer of Bortezomib, it serves crucial roles in anti-cancer research applications, providing insights into therapeutic strategies that exploit proteasome inhibition in malignancies.
(1S,2S)-Bortezomib is a selective proteasome inhibitor with a high affinity for the 20S proteasome, exhibiting a Ki of 0.6 nM. This compound disrupts the cell cycle and induces apoptosis by targeting a threonine residue, ultimately leading to the inhibition of NF-κB signaling. As an enantiomer of Bortezomib, it serves crucial roles in anti-cancer research applications, providing insights into therapeutic strategies that exploit proteasome inhibition in malignancies.
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