2-(2,6-Dioxopiperidin-3-yl)phthalimidine-piperazine-C-piperidine hydrochloride

Catalog No.: A80335
E3 Ligase Ligand-Linker Conjugate
2-(2,6-Dioxopiperidin-3-yl)phthalimidine-piperazine-C-piperidine hydrochloride serves as an E3 ligase ligand-linker conjugate, incorporating a CRBN-based ligand and linker. This compound is designed for the synthesis of PROTAC (proteolysis-targeting chimeras), facilitating targeted protein degradation. Its utility lies in advancing research in therapeutic applications that involve modulation of protein homeostasis through targeted neosome pathways.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Description2-(2,6-Dioxopiperidin-3-yl)phthalimidine-piperazine-C-piperidine hydrochloride serves as an E3 ligase ligand-linker conjugate, incorporating a CRBN-based ligand and linker. This compound is designed for the synthesis of PROTAC (proteolysis-targeting chimeras), facilitating targeted protein degradation. Its utility lies in advancing research in therapeutic applications that involve modulation of protein homeostasis through targeted neosome pathways.
Product Information
Catalog NumA80335
FormulaC23H32ClN5O3
CAS Number2806001-88-5
SMILESO=C1NC(C(CC1)N2C(C3=CC=C(N4CCN(CC5CCNCC5)CC4)C=C3C2)=O)=O.Cl.[x]
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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