PROTACs

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  1. Pomalidomide-C2-NH2

    Catalog No. A18855
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    E3 ligase ligand-linker conjugate
    Pomalidomide-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a PEG linker used in PROTAC technology. Learn More
  2. Pomalidomide-C2-NH2 hydrochloride

    Catalog No. A21768
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    E3 ligase ligand-linker conjugate
    Pomalidomide-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology. Learn More
  3. (S,R,S)-AHPC-PEG4-NH2

    Catalog No. A21671
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    E3 ligase ligand-linker conjugate
    (S,R,S)-AHPC-PEG4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology. Learn More
  4. (S,R,S)-AHPC-PEG2-NH2

    Catalog No. A21665
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    E3 ligase ligand-linker conjugate
    (S,R,S)-AHPC-PEG2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in PROTAC technology. Learn More
  5. (S,R,S)-AHPC-PEG3-NH2

    Catalog No. A21660
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    E3 ligase ligand-linker conjugate
    (S,R,S)-AHPC-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology. Learn More
  6. Thalidomide-O-amido-C6-NH2 (TFA)

    Catalog No. A21639
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    E3 ligase ligand-linker conjugate
    Thalidomide-O-amido-C6-NH2 TFA (Cereblon Ligand-Linker Conjugates 11 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Learn More
  7. Thalidomide-O-amido-PEG2-C2-NH2 (TFA)

    Catalog No. A21634
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    E3 ligase ligand-linker conjugate
    Thalidomide-O-amido-PEG2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology. Learn More
  8. Pomalidomide-PEG4-Ph-NH2

    Catalog No. A12066
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    E3 ligase ligand-linker conjugate
    Pomalidomide-PEG4-Ph-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology. Learn More
  9. CCK2R Ligand-Linker Conjugates 1

    Catalog No. A18411
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    ligand-linker conjugate
    CCK2R Ligand-Linker Conjugates 1 is a ligand-linker conjugate, which conjugates to the cytotoxic antimicrotubule agents Desacetyl Vinblastine Hydrazide (DAVBH) and Tubulysin B Hydrazide (TubBH) via a hydrophilic peptide linker. Learn More
  10. (S,R,S)-AHPC-C3-NH2

    Catalog No. A18818
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    E3 ligase ligand-linker conjugate
    (S,R,S)-AHPC-C3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used in PROTAC technology. Learn More
  11. Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH

    Catalog No. A18842
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    E3 ligase ligand-linker conjugate
    Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology. Learn More
  12. Thalidomide-O-amido-C3-NH2 (TFA)

    Catalog No. A21801
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    E3 ligase ligand-linker conjugate
    Thalidomide-O-amido-C3-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Learn More
  13. cIAP1 Ligand-Linker Conjugates 15 hydrochloride

    Catalog No. A21758
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    E3 ligase ligand-linker conjugate
    cIAP1 Ligand-Linker Conjugates 15 hydrochloride incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 15 hydrochloride can be used to design SNIPERs. Learn More
  14. cIAP1 Ligand-Linker Conjugates 11 Hydrochloride

    Catalog No. A21753
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    E3 ligase ligand-linker conjugate
    cIAP1 Ligand-Linker Conjugates 11 Hydrochloride incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 11 Hydrochloride can be used to design SNIPERs. Learn More
  15. Lenalidomide-C5-NH2

    Catalog No. A18414
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    Lenalidomide-based Cereblon ligand
    Lenalidomide-C5-NH2 is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-NH2 can be connected to the ligand for protein by a linker to form PROTACs. Learn More
  16. E3 ligase Ligand 9

    Catalog No. A19051
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    E3 ubiquitin ligase ligand
    E3 ligase Ligand 9 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 9 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. Learn More
  17. E3 ligase Ligand 10

    Catalog No. A19045
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    E3 ubiquitin ligase ligand
    E3 ligase Ligand 10 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 10 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins. Learn More
  18. E3 ligase Ligand 14

    Catalog No. A19028
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    E3 ubiquitin ligase ligand
    E3 ligase Ligand 14 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 14 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins. Learn More
  19. Thalidomide fluoride

    Catalog No. A12144
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    Thalidomide-based Cereblon ligand
    Thalidomide fluoride (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1 (HY-129966). Learn More
  20. VH032-cyclopropane-F

    Catalog No. A18417
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    VH032-based VHL ligand
    VH032-cyclopropane-F is the VH032-based VHL ligand. VH032-cyclopropane-F can be connected to the ligand for protein (e.g., SMARCA BD ligand) by a linker to form PROTACs (e.g., PROTAC 1). Learn More
  21. TD-106

    Catalog No. A18595
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    CRBN modulator
    TD-106 is a cereblon (CRBN) modulator, which can be used for targeted protein degradation. BRD4 PROTACs with TD-106 induce BRD4 degradation. Learn More
  22. BC-1215

    Catalog No. A18605
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    FBXO3 inhibitor
    BC-1215 is an inhibitor of F-box protein 3 (FBXO3, a ubiquitin E3 ligase component, IC50=0.9 μg/mL for IL-1β release). BC-1215 decreases Fbxo3-Fbxl2 interaction and prevents SCFFbxo3 catalyzed Fbxl2 ubiquitination. Learn More
  23. PROTAC BET degrader-2

    Catalog No. A18785
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    PROTAC BET degrader
    PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins with an IC50 value of 9.6 nM in cell growth inhibition in the RS4;11 cells and capable of achieving tumor regression. Learn More
  24. dBET57

    Catalog No. A19133
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    BRD4BD1degrader
    dBET57 is a potent and selective degrader of BRD4BD1 based on the PROTAC technology. Learn More
  25. MZP-55

    Catalog No. A19415
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    BRD3/4 degrader
    MZP-55 is a selective degrader of BRD3/4 based on PROTAC technology, with a Kd of 8 nM for Brd4BD2. Learn More
  26. MZP-54

    Catalog No. A19426
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    BRD3/4 degrader
    MZP-54 is a selective degrader of BRD3/4 based on PROTAC technology, with a Kd of 4 nM for Brd4BD2. Learn More
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    MZ1

    Catalog No. A17014
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    BRD4 protein degrader
    MZ1 is a potent inducer of reversible, long-lasting and selective removal of BRD4 over BRD2 and BRD3. Learn More
  27. dBET1

    Catalog No. A16858
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    BRD4 protein degrader
    dBET1 is a potent BRD4 protein degrader based on PROTAC technology with an EC50 of 430 nM. Learn More
  28. FKBP12 PROTAC dTAG-7

    Catalog No. A19081
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    heterobifunctional degrader
    FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional degrader. Learn More
  29. PROTAC ERRα ligand 2

    Catalog No. A18939
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    ERRα inverse agonist
    PROTAC ERRα ligand 2 is an estrogen-related receptor α (ERRα) inverse agonist with an IC50 of 5.67 nM. PROTAC ERRα ligand 2 (IC50=5.67 nM) displays a ~11-fold improved potency than XCT790 (IC50=61.3 nM). Learn More
  30. PROTAC ERRα Degrader-1

    Catalog No. A18910
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    ERRα Degrader
    PROTAC ERRα Degrader-1 comprises a MDM2 ligand binding group, a linker and an estrogen-related receptor alpha (ERRa) binding group. PROTAC ERRα Degrader-1 is an estrogen-related receptor alpha (ERRa) degrader. Learn More
  31. PROTAC ERRα Degrader-2

    Catalog No. A18904
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    ERRa degrader
    PROTAC ERRalpha Degrader-2 comprises a MDM2 ligand binding group, a linker and an estrogen-related receptor alpha (ERRa) binding group. PROTAC ERRalpha Degrader-2 is an estrogen-related receptor alpha (ERRa) degrader. Learn More
  32. PROTAC CRBN Degrader-1

    Catalog No. A18863
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    CRBN degrader
    PROTAC CRBN Degrader-1 comprises a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group. PROTAC CRBN Degrader-1 is an cereblon (CRBN) degrader. Learn More
  33. PROTAC FLT-3 degrader 1

    Catalog No. A18682
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    FLT-3 ITD degrader
    PROTAC FLT-3 degrader 1 is an FLT-3 internal tandem duplication (ITD) degrader with an IC50 0.6 nM. Anti-proliferative activity; apoptosis induction. Learn More
  34. PROTAC ER Degrader-3

    Catalog No. A18519
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    PROTAC ER Degrader-3 is an intermediate for synthesis of PAC. PAC, consists the ADCs linker and PROTACs, conjugated to an antibody. PAC extracts from patent WO2017201449A1, compound LP2. PAC conjugated to an antibody is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab). Learn More
  35. ARV-771

    Catalog No. A13255
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    BET degrader
    ARV-771 is a potent BET degrader based on PROTAC technology with Kds of 34, 4.7, 8.3, 7.6, 9.6, and 7.6 nM for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1), and BRD4(2), respectively. Learn More
  36. BETd-260

    Catalog No. A12563
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    BET degrader
    BETd-260 is a potent BET degrader based on PROTAC technology, with as low as 30 pM against BRD4 protein in RS4;11 leukemia cell line. Learn More
  37. PROTAC Sirt2 Degrader-1

    Catalog No. A20005
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    Sirt2 degrader
    PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide cereblon ligand for E3 ubiquitin ligase. Learn More
  38. THAL-SNS-032

    Catalog No. A19088
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    CDK9 degrader PROTAC
    THAL-SNS-032 is a selective CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN). Learn More
  39. Gefitinib-based PROTAC 3

    Catalog No. A19093
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    Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectively. Learn More
  40. ZXH-3-26

    Catalog No. A18399
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    PROTAC BRD4 degrader
    ZXH-3-26 is a selective PROTAC BRD4 degrader with a DC50/5h (DC50/5h referring to half-maximal degradation after 5 hours of treatment) of ~ 5 nM. Learn More
  41. dMCL1-2

    Catalog No. A18378
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    MCL-1/PROTAC degrader
    dMCL1-2 is a potent and selective degrader of myeloid cell leukemia 1 (MCL1) based on PROTAC, which binds to MCL1 with a KD of 30 nM. dMCL1-2 activats the cellular apoptosis machinery by degradation of MCL1. Learn More
  42. PROTAC Mcl1 degrader-1

    Catalog No. A18373
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    Mcl-1 inhibitor
    PROTAC Mcl1 degrader-1 (compound C3), a proteolysis targeting chimera (PROTAC), is a potently and selectively Mcl-1 inhibitor with an IC50 of 0.78 μM. Learn More
  43. PROTAC Bcl2 degrader-1

    Catalog No. A18355
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    degrader
    PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 μM; DC50, 3.0 μM) and Mcl-1 (IC50, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1. Learn More
  44. A1874

    Catalog No. A18735
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    BRD4-degrading PROTAC
    A1874 is a nutlin-based and BRD4-degrading PROTAC with a DC50 of 32 nM (induce BRD4 degradation in cells). Effective in inhibiting many cancer cell lines proliferation. Learn More
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    MD-224

    Catalog No. A18712
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    MDM2 degrader
    MD-224 is a first-in-class and highly potent small-molecule human murine double minute 2 (MDM2) degrader based on the proteolysistargeting chimera (PROTAC) concept. MD-224 has the potential to be a new class of anticancer agent. Learn More
  45. VZ185

    Catalog No. A18685
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    dual BRD7/9 PROTAC degrader
    VZ185 is a potent, fast, and selective dual BRD7/9 PROTAC degrader with DC50s of 4.5 and 1.8 nM, respectively. Learn More
  46. SJFα

    Catalog No. A18602
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    13-atom linker PROTAC
    SJFα is a 13-atom linker PROTAC. SJFα degrades p38α with a DC50 of 7.16??nM, but is far less effective at degrading p38δ (DC50=299?nM) and does not degrade the other p38 isoforms (β and γ) at concentrations up to 2.5??M. Learn More
  47. SJFδ

    Catalog No. A18599
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    10-atom linker PROTAC
    SJFδ is a 10-atom linker PROTAC. SJFδ degrades p38δ with a DC50 of 46.17?nM, but does not degrade p38α, p38β, or p38γ. Learn More
  48. MT-802

    Catalog No. A18589
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    BTK degrader
    MT-802 is a potent BTK degrader based on PROTAC technology, with a DC50 of 1 nM. MT-802 has potential to treat C481S mutant chronic lymphocytic leukemia (CLL). Learn More

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