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Biological Activity
2,4-Diamino-6-hydroxypyrimidine is a specific GTP cyclohydrolase I inhibitor (the rate-limiting enzyme in de novo pterin synthesis), blocks BH4 synthesis and suppresses NO production.
| In vitro | DMSO | 21 mg/mL (166.5 mM) | |
| Water | 5 mg/mL (39.64 mM) | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 79.29 mL | 396.45 mL | 792.9 mL |
| 0.5 mM | 15.86 mL | 79.29 mL | 158.58 mL |
| 1 mM | 7.93 mL | 39.64 mL | 79.29 mL |
| 5 mM | 1.59 mL | 7.93 mL | 15.86 mL |
*The above data is based on the productmolecular weight 126.12. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A13500 |
|---|---|
| Actions | Inhibitor |
| CAS No. | CAS: 56-06-4 |
| Formula | C4H6N4O |
| M. Wt | 126.12 |
| Purity | >98% |
| SMILES | O=C1N=C(N)NC(N)=C1 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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