20(S)-Hydroxycholesterol

Catalog No.: A21850

Smo allosteric activator

20(S)-Hydroxycholesterol

20(S)-Hydroxycholesterol Chemical Structure

CAS NO. 516-72-3

20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) is an allosteric activator of the oncoprotein smoothened (Smo) that activates the hedgehog (Hh) signaling pathway with an EC50 of 3 μM in a gene transcription reporter assay using NIH3T3 cells.

Availability: In stock

Package Price Qty
5 mg
$189.00
10 mg
$326.00
50 mg
$966.00
100 mg
$1,932.00
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Biological Activity

20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) is an allosteric activator of the oncoprotein smoothened (Smo) that activates the hedgehog (Hh) signaling pathway with an EC50 of 3 μM in a gene transcription reporter assay using NIH3T3 cells.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.84 mL 124.18 mL 248.35 mL
0.5 mM 4.97 mL 24.84 mL 49.67 mL
1 mM 2.48 mL 12.42 mL 24.84 mL
5 mM 0.5 mL 2.48 mL 4.97 mL

*The above data is based on the productmolecular weight 402.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A21850
Actions Activator
CAS No. 516-72-3
Formula C27H46O2
M. Wt 402.65
Purity >98%
Synonyms 20α-Hydroxycholesterol
SMILES C[[email protected]@]1([[email protected]@]2([H])[[email protected]@](C)(O)CCCC(C)C)[[email protected]](CC2)([H])[[email protected]@](CC=C3[[email protected]@]4(CC[[email protected]](O)C3)C)([H])[[email protected]]4([H])CC1
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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