2BAct is a selective activator of the eukaryotic initiation factor 2B (eIF2B) with an EC50 of 33 nM. This compound effectively prevents neurological defects associated with a chronic integrated stress response, making it a valuable tool for research in neurobiology and stress response mechanisms. Additionally, 2BAct demonstrates enhanced solubility and improved pharmacokinetic properties compared to the eIF2B activator ISRIB trans-isomer.
2BAct is a selective activator of the eukaryotic initiation factor 2B (eIF2B) with an EC50 of 33 nM. This compound effectively prevents neurological defects associated with a chronic integrated stress response, making it a valuable tool for research in neurobiology and stress response mechanisms. Additionally, 2BAct demonstrates enhanced solubility and improved pharmacokinetic properties compared to the eIF2B activator ISRIB trans-isomer.
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